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Article
Open AccessPatterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin’s lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group
Response-adapted treatment using early interim functional imaging with PET after two cycles of chemotherapy (PET-2) for advanced-stage Hodgkin’s lymphoma (AS-HL) is the standard of care in several countries. H...
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Article
Open AccessFollow-up of the GHSG HD16 trial of PET-guided treatment in early-stage favorable Hodgkin lymphoma
The primary analysis of the GHSG HD16 trial indicated a significant loss of tumor control with PET-guided omission of radiotherapy (RT) in patients with early-stage favorable Hodgkin lymphoma (HL). This analys...
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Article
Open AccessThreshold for defining PSMA-positivity prior to 177Lu-PSMA therapy: a comparison of [68Ga]Ga-PSMA-11 and [18F]F-DCFPyL in metastatic prostate cancer
In 2022, the American Food and Drug Administration and the European Medicines Agency approved [177Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membra...
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Article
FDG-Positronenemissionstomographie-Computertomographie und neue Chancen zur Therapiesteuerung
Die Nutzung der Positronenemissionstomographie-Computertomographie mit 18F‑Fluordesoxyglukose (FDG-PET-CT) vor, während und nach Abschluss der Chemotherapie wurde untersucht, um die Behandlungsintensität beim Hod...
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Article
Open AccessPredictive value of baseline metabolic tumor volume in early-stage favorable Hodgkin Lymphoma – Data from the prospective, multicenter phase III HD16 trial
18F -fluorodeoxyglucose (FDG) positron emission tomography (PET) plays an important role in the staging and response assessment of lymphoma patients. Our aim was to explore the predictive relevance of metabolic ....
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Article
Open AccessTranslational Development of a Zr-89-Labeled Inhibitor of Prostate-specific Membrane Antigen for PET Imaging in Prostate Cancer
We present here a Zr-89-labeled inhibitor of prostate-specific membrane antigen (PSMA) as a complement to the already established F-18- or Ga-68-ligands.
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Article
Open Access[18F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer
PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [18F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemica...
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Chapter
Radioiodine Therapy for Benign Thyroid Disease
The success rate of radioiodine (I-131) therapy for toxic goiter and solitary hyperfunctioning nodules depends on thyroid volume, compensation of hyperthyroidism, timing of the withdrawal of antithyroid drugs,...
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Article
Open AccessBiodistribution and radiation dosimetry of [18F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer
We investigated the whole-body distribution and the radiation dosimetry of [18F]-JK-PSMA-7, a novel 18F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.
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Article
Open AccessImpact of different approaches to calculation of treatment activities on achieved doses in radioiodine therapy of benign thyroid diseases
Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...
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Article
Positronenemissionstomographie beim Hodgkin-Lymphom
Die FDG-PET (Fluordesoxyglucose-Positronenemissionstomographie) ist eine Standarduntersuchung in der Bestimmung des Stadiums und des Therapieansprechens des Hodgkin-Lymphoms geworden.
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Article
Lacrimal Glands May Represent Organs at Risk for Radionuclide Therapy of Prostate Cancer with [177Lu]DKFZ-PSMA-617
Calculating the absorbed dose is important for the determination of risk and therapeutic benefit of internal radiation therapy. The aim of this study was to perform image-based absorbed dose calculation for cr...
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Article
Impact of PET/CT image reconstruction methods and liver uptake normalization strategies on quantitative image analysis
In oncological imaging using PET/CT, the standardized uptake value has become the most common parameter used to measure tracer accumulation. The aim of this analysis was to evaluate ultra high definition (UHD)...
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Article
Erratum to: Impact of PET/CT image reconstruction methods and liver uptake normalization strategies on quantitative image analysis
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Article
Open AccessComparison of [18F]DCFPyL and [68Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer
Gallium-68 (Ga-68)-labeled tracers for imaging expression of the prostate-specific membrane antigen (PSMA) such as the [68Ga]Ga-PSMA-HBED-CC have already demonstrated high potential for the detection of recurrent...
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Article
Open AccessCharacterization of SnO2-based 68Ge/68Ga generators and 68Ga-DOTATATE preparations: radionuclide purity, radiochemical yield and long-term constancy
With the increasing utilization of 68Ge-68Ga radionuclide generators, 68Ga labelled peptides like DOTATATE are receiving more attention in nuclear medicine. On the one hand, the long half-life of the parent nucli...
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Chapter
Ablation Therapy with Radioiodine in Adults and Children with Differentiated Thyroid Cancer
Ablation with radioiodine is an effective and low-risk-therapy modality in adults and children with differentiated thyroid cancer. According to international guidelines, radioiodine ablation is indicated in hi...
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Chapter
Radioiodine Therapy of Hyperthyroidism (Toxic Goiter, Hyperfunctioning Nodule) and Non-Toxic Goiter: Procedures and Guidelines
The purpose of the present chapter on the radioiodine-131 (I-131) therapy of benign thyroid disorders is to provide advice to nuclear medicine clinicians on how to treat toxic goiter, hyperfunctioning nodules...
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Article
Predictive value of early and late residual 18F-fluorodeoxyglucose and 18F-fluorothymidine uptake using different SUV measurements in patients with non-small-cell lung cancer treated with erlotinib
To evaluate the predictive value of early and late residual 18F-fluorodeoxyglucose (FDG) and 18F-fluorothymidine (FLT) uptake using different SUV measurements in PET in patients with advanced non-small-cell lung ...
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Article
Exhalation of 131I after radioiodine therapy: measurements in exhaled air
A considerable amount of radioiodine is exhaled after radioiodine therapy leading to unwanted radiation exposure through inhalation. This study focused on the concentration of radioactivity exhaled and its che...
