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  1. No Access

    Article

    A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells

    The self-propagation of misfolded conformations of tau underlies neurodegenerative diseases, including Alzheimer's. There is considerable interest in discovering the minimal sequence and active conformational ...

    Jan Stöhr, Haifan Wu, Mimi Nick, Yibing Wu, Manasi Bhate… in Nature Chemistry (2017)

  2. No Access

    Article

    Application of amino acid type-specific 1H- and 14N-labeling in a 2H-, 15N-labeled background to a 47 kDa homodimer: Potential for NMR structure determination of large proteins

    NMR investigations of larger macromolecules (>20 kDa) are severely hindered by rapid 1H and 13C transverse relaxation. Replacement of non-exchangeable protons with deuterium removes many efficient 1H-1H and 1H...

    Mark J.S. Kelly, Cornelia Krieger, Linda J. Ball, Yihua Yu… in Journal of Biomolecular NMR (1999)