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  1. No Access

    Article

    Distinction of lymphoid and myeloid clonal hematopoiesis

    Clonal hematopoiesis (CH) results from somatic genomic alterations that drive clonal expansion of blood cells. Somatic gene mutations associated with hematologic malignancies detected in hematopoietic cells of...

    Abhishek Niroula, Aswin Sekar, Mark A. Murakami, Mark Trinder… in Nature Medicine (2021)

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    Article

    Signalling input from divergent pathways subverts B cell transformation

    Malignant transformation of cells typically involves several genetic lesions, whose combined activity gives rise to cancer1. Here we analyse 1,148 patient-derived B-cell leukaemia (B-ALL) samples, and find that i...

    Lai N. Chan, Mark A. Murakami, Mark E. Robinson, Rebecca Caeser, Teresa Sadras… in Nature (2020)

  3. No Access

    Article

    Targeting minimal residual disease: a path to cure?

    Improved therapies have allowed many patients with cancer to achieve complete remission, but they retain minimal residual disease (MRD), which causes relapse. This Opinion article argues that iterative detecti...

    Marlise R. Luskin, Mark A. Murakami, Scott R. Manalis… in Nature Reviews Cancer (2018)

  4. No Access

    Article

    The next best thing

    A patient's tumour cells can be transplanted into a mouse to provide a model for analysis and drug testing. A panel of paediatric solid tumour models has been extensively characterized and made freely available.

    Mark A. Murakami, David M. Weinstock in Nature (2017)

  5. No Access

    Article

    Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate

    The efficacy of cancer drugs is profiled by measuring changes in the mass of single tumor cells.

    Mark M Stevens, Cecile L Maire, Nigel Chou, Mark A Murakami… in Nature Biotechnology (2016)

  6. No Access

    Article

    High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays

    Heterogeneity in growth phenotypes and drug susceptibility in bacterial and mammalian cells are assayed at the single-cell level using multiplexed resonant mass sensors.

    Nathan Cermak, Selim Olcum, Francisco Feijó Delgado… in Nature Biotechnology (2016)