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Article
Open AccessDouble-level torsional osteotomy a treatment for the ‘inwardly pointing knee’ syndrome
A ‘inwardly pointing knee’ syndrome is a combined torsional deformity with increased femoral internal and tibial external torsion. After clinical and radiological verification of the torsional deformity and un...
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Article
Open AccessBiomechanical comparison of acetabular fracture fixation with stand-alone THA or in combination with plating
A common surgical treatment in anterior column acetabular fractures with preexisting osteoarthritis is THA, which is commonly combined with plate osteosynthesis. Implantation of a solitary revision cup cranial...
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Article
Open AccessEarly biomechanical outcome in patients with acetabular fractures treated using the pararectus approach: a gait and stair climb analysis study
Patients with surgically treated acetabular fractures using extensive dissection of hip muscles demonstrate an incomplete biomechanical recovery and limited joint mobility during movement. The purpose of this ...
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Article
Open AccessThe pararectus approach for internal fixation of acetabular fractures involving the anterior column: evaluating the functional outcome
Aim of this retrospective analysis of prospectively collected data was to evaluate the functional mid-term outcome two years after open reduction and internal fixation of acetabular fractures involving the ant...
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Article
Alcohol Binge Reduces Systemic Leukocyte Activation and Pulmonary PMN Infiltration After Blunt Chest Trauma and Hemorrhagic Shock
Blunt chest (thoracic) trauma (TxT) and hemorrhagic shock (HS)-induced local and systemic inflammation with increased neutrophil activity often result in an impaired organ function. Next to increasing the trau...
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Article
Open AccessThe molecular fingerprint of lung inflammation after blunt chest trauma
After severe blunt chest trauma, the development of an acute lung injury (ALI) is often associated with severe or even lethal complications. Especially in multiple injured patients after blunt chest trauma ALI...
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Article
Open AccessThe immune response after fracture trauma is different in old compared to young patients
Despite significant medical progress and improved treatment, surgical procedures of proximal femur fractures in older patients are still associated with a high postoperative complication and mortality rate. Re...
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Chapter
Granzyme B: A New Crossroad of Complement and Apoptosis
In response to severe tissue trauma, several “molecular danger” sensing and signaling pathways are activated, especially the complement and the apoptosis cascade. Although possible crossroads between both syst...
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Article
Is the function of alveolar macrophages altered following blunt chest trauma?
The purpose of this study was to characterize the local pulmonary inflammatory environment and to elucidate alterations of alveolar macrophage (AMØ) functions after blunt chest trauma.
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Article
Open AccessEpithelial Cell Apoptosis and Neutrophil Recruitment in Acute Lung Injury—A Unifying Hypothesis? What We Have Learned from Small Interfering RNAs
In spite of protective ventilatory strategies, Acute Lung Injury (ALI) remains associated with high morbidity and mortality. One reason for the lack of therapeutic options might be that ALI is a co-morbid even...
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Protocol
Hydrodynamic Delivery of siRNA in a Mouse Model of Sepsis
The use of siRNA in vivo as well as in animal models has become more widespread in recent years, leading to further questions as to the best mode of delivery that will achieve optimal knockdown. While the exact m...
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Article
No good deed goes unpunished!
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Article
Interleukin-6 (IL-6) – an Early Marker of Chest Trauma
Background and Objective: Although in recent years methods in emergency medicine have been remarkably improved, thoracic trauma remains associated with high mortality. To select adequate treatmen...
