9 Result(s)
within
Markus S. Huber-Lang
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Article
Open AccessThe immune response after fracture trauma is different in old compared to young patients
Despite significant medical progress and improved treatment, surgical procedures of proximal femur fractures in older patients are still associated with a high postoperative complication and mortality rate. Re...
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Article
Open AccessMolecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"?
Trauma represents the leading cause of death among young people in industrialized countries. Recent clinical and experimental studies have brought increasing evidence for activation of the innate immune system...
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Article
Is the function of alveolar macrophages altered following blunt chest trauma?
The purpose of this study was to characterize the local pulmonary inflammatory environment and to elucidate alterations of alveolar macrophage (AMØ) functions after blunt chest trauma.
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Article
Pathophysiology of septic encephalopathy - an unsolved puzzle
The exact cellular and molecular mechanisms of sepsis-induced encephalopathy remain elusive. The breakdown of the blood-brain barrier (BBB) is considered a focal point in the development of sepsis-induced brai...
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Article
Immunodesign of experimental sepsis by cecal ligation and puncture
Sepsis remains a prevalent clinical challenge and the underlying pathophysiology is still poorly understood. To investigate the complex molecular mechanisms of sepsis, various animal models have been developed...
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Article
Open AccessMolecular Events in the Cardiomyopathy of Sepsis
Septic cardiomyopathy is a well-described complication of severe sepsis and septic shock. However, the interplay of its underlying mechanisms remains enigmatic. Consequently, we constantly add to our pathophys...
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Article
Phagocyte-derived catecholamines enhance acute inflammatory injury
The discovery that phagocytic blood cells (macrophages and neutrophils) are a significant source of catecholamines (noradrenaline and adrenaline), and can cause reinforcement of the acute inflammatory response...
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Chapter
Role of Complement in Multi-Organ Dysfunction Syndrome
In critically ill humans with manifestation of a systemic inflammatory response syndrome (SIRS), the onset of multi-organ dysfunction syndrome (MODS) is a well known complication that is associated with a high...
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Chapter
Role of Complement in Acute Lung Injury
Because the respiratory tract is continuously exposed to pathogens and/or particles in the inhaled air, appropriate immune defense mechanisms have evolved to prevent lung inflammatory injury. The tight interpl...
