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Article
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review
Migraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine a...
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Article
Open AccessProton pump inhibitor-induced gut dysbiosis and immunomodulation: current knowledge and potential restoration by probiotics
Proton pump inhibitors (PPIs) are the most commonly prescribed drugs for the treatment of non-erosive reflux disease (NERD), ulcers associated with non-steroidal anti-inflammatory drugs (NSAIDs), esophagitis, ...
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Article
Open AccessModulation of allergic contact dermatitis via gut microbiota modified by diet, vitamins, probiotics, prebiotics, and antibiotics
Allergic contact dermatitis is one of the most common recorded occupational diseases. There are many different substances that the skin comes into contact with on a daily basis and that can cause ACD, e.g., pr...
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Article
Open AccessThe potential action of SSRIs in the treatment of skin diseases including atopic dermatitis and slow-healing wounds
Selective serotonin reuptake inhibitors (SSRIs) are used to treat affective and anxiety disorders. Antidepressants have also been shown to have antimicrobial and immunomodulatory effects, which may affect the ...
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Article
Open AccessChanges in γδT Cells in Peripheral Blood of Patients with Ulcerative Colitis Exacerbations
The role of γδT cells in ulcerative colitis (UC) is well confirmed in experimental animals and demonstrated in many clinical observations. Recent investigations have indicated that UC is associated with severa...
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Article
Open AccessPerinatal treatment of parents with the broad-spectrum antibiotic enrofloxacin aggravates contact sensitivity in adult offspring mice
Antibiotics, while eliminating pathogens, also partially deplete commensal bacteria. Antibiotic-induced dysbiosis may contribute to the observed rise in “immune-mediated” diseases, including autoimmunity and a...
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Article
Cyclophosphamide-modified murine peritoneal macrophages induce CD4+ T contrasuppressor cells that protect contact sensitivity T effector cells from suppression
Cyclophosphamide (CY) is one of the most widely used alkylating agents in the treatment of various cancers and some autoimmune diseases. Numerous reports suggest that CY exerts immunoregulatory effects. Animal...
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Article
Erratum to “Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice”
The authors wish to note an incorrectly listed financial support grant. The National Science Centre grants 2011/01/B/NZ6/00300 and 2012/05/B/NZ6/00997 were inadvertently listed. The authors regret this error. ...
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Article
Erratum to “Partial depletion of natural gut flora by antibiotic aggravates collagen induced arthritis (CIA) in mice”
The authors wish to note an incorrectly listed financial support grants 2011/01/B/NZ6/00300 and 2011/03/B/NZ6/00801. The National Science Centre grants were inadvertently listed. The authors regret this error.
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Article
Erratum to “Oral treatment with enrofloxacin early in life promotes Th2-mediated immune response in mice”
The authors wish to note an incorrectly listed financial support grants. The National Science Centre grants 2011/01/B/NZ6/00300 and 2012/05/B/NZ6/00997 were inadvertently listed. The authors regret this error....
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Article
Erratum to “Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs”
The authors wish to note an incorrectly listed financial support grant. The National Science Centre grant 2011/01/B/NZ6/00300 was inadvertently listed. The authors regret this error. The correct Acknowledgemen...
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Article
Erratum to “Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice”
The authors wish to note an incorrectly listed financial support grant. The National Science Centre grant UMO-2011/01/B/NZ6/00300 was inadvertently listed. The authors regret this error. The correct Acknowledg...
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Article
Erratum to “Epicutaneous immunization with protein antigen TNP-Ig and NOD2 ligand muramyl dipeptide (MDP) reverses skin-induced suppression of contact hypersensitivity”
The authors wish to note an incorrectly listed financial support grant. The National Science Centre grants UMO-2012/05/B/NZ6/00997 and UMO-2011/03/B/NZ6/00821 were inadvertently listed. The authors regret this...
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Article
Erratum to “Epicutaneous immunization with hapten-conjugated protein antigen alleviates contact sensitivity mediated by three different types of effector cells”
The authors wish to note an incorrectly listed financial support grant. The National Science Centre grant 2011/01/B/NZ6/00300 was inadvertently listed. The authors regret this error. The correct Acknowledgemen...
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Article
Transdermal immunotherapy: Past, present and future
The human skin plays an important role in thermal regulation, the maintenance of the correct water and electrolyte balance; it is also the main source of the vitamin D for the organism. Moreover, the skin form...
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Article
Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4+ CD8+ T suppressor cells that protect from collagen-induced arthritis (CIA)
We have shown previously that epicutaneous (EC) immunization with protein antigen induces T suppressor cells that alleviate inflammatory response in contact hypersensitivity reactions, in an animal model of mu...
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Article
Oral treatment with enrofloxacin early in life promotes Th2-mediated immune response in mice
Th2 lymphocytes play a crucial role in the development of allergy. These pathologies are caused by coordinated production of the cytokines IL-4, IL-5 and IL-13 that regulate the activity of eosinophils, basoph...
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Article
Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice
Epicutaneous (EC) immunization is a potential new strategy of a needle-free and self-administrable immunization by using a topically applied patch to deliver vaccine. We have previously shown that EC immunizat...
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Article
Partial depletion of natural gut flora by antibiotic aggravates collagen induced arthritis (CIA) in mice
Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the adult population and occurs twice as frequently among women than men. At present it is accepted that pathogenesis of RA ...
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Article
Skin-induced tolerance as a new needle free therapeutic strategy
This article summarizes current knowledge about a new subject called “skin induced tolerance”. Suppression is induced via epicutaneous (EC) immunization with a protein antigen and is described in Th1, Tc1 and NK ...
