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Article
Open AccessCorrection to: Alzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAlzheimer’s genetic risk factor FERMT2 (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner
Although APP metabolism is being intensively investigated, a large fraction of its modulators is yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the func...
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Article
Open AccessDiabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques
Alzheimer’s disease (AD) is the most common neurodegenerative disease and type 2 diabetes (T2D) plays an important role in conferring the risk for AD. Although AD and T2D share common features, the common mole...
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Article
Open AccessThe Alzheimer’s disease-associated protective Plcγ2-P522R variant promotes immune functions
Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease...
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Article
Open AccessDHCR24 exerts neuroprotection upon inflammation-induced neuronal death
DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain ar...
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Article
Open AccessRegulation of key proteins in Alzheimer’s disease molecular pathogenesis by ubiquilin-1
