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  1. Article

    Open Access

    Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD

    The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is ...

    Tetsuhiro Ueda, Toshihide Takeuchi… in Acta Neuropathologica Communications (2024)

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  2. No Access

    Article

    Insulin sensitivity and pancreatic β-cell function in patients with primary aldosteronism

    Primary aldosteronism (PA) is associated with an increased risk for dysglycemia. However, the effects of hyperaldosteronism on insulin sensitivity and β-cell function are unclear.

    Shivraj Grewal, Andin Fosam, Liam Chalk, Arjun Deven, Mari Suzuki… in Endocrine (2021)

  3. Article

    Open Access

    Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

    Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular in...

    Rubén Hervás, María del Carmen Fernández-Ramírez, Albert Galera-Prat… in BMC Biology (2021)

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  4. No Access

    Article

    Glycolaldehyde induces sensory neuron death through activation of the c-Jun N-terminal kinase and p-38 MAP kinase pathways

    Glycolaldehyde (GA) is a highly reactive hydroxyaldehyde and one of the glycolytic metabolites producing advanced glycation endproducts (AGEs), but its toxicity toward neurons and Schwann cells remains unclear...

    Tomoyo Akamine, Shizuka Takaku, Mari Suzuki, Naoko Niimi… in Histochemistry and Cell Biology (2020)

  5. Article

    Open Access

    Suppression of autophagic activity by Rubicon is a signature of aging

    Autophagy, an evolutionarily conserved cytoplasmic degradation system, has been implicated as a convergent mechanism in various longevity pathways. Autophagic activity decreases with age in several organisms, ...

    Shuhei Nakamura, Masaki Oba, Mari Suzuki, Atsushi Takahashi… in Nature Communications (2019)

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  6. No Access

    Article

    Necessity of performing voiding cystourethrography for children with unilateral multicystic dysplastic kidney

    The purpose of this study was to resolve the clinical question as to whether all patients with unilateral multicystic dysplastic kidney (MCDK) should receive voiding cystourethrography (VCUG).

    Kazuna Yamamoto, Koichi Kamei, Mai Sato, Masao Ogura, Mari Suzuki… in Pediatric Nephrology (2019)

  7. Article

    Open Access

    Expression of parathyroid hormone/parathyroid hormone-related peptide receptor 1 in normal and diseased bladder detrusor muscles: a clinico-pathological study

    To investigate the expression of parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor 1 (PTH1R) in clinical specimens of normal and diseased bladders. PTHrP is a unique stretch-induced endogenous det...

    Nobuyuki Nishikawa, Rie Yago, Yuichiro Yamazaki, Hiromitsu Negoro… in BMC Urology (2015)

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  8. No Access

    Article

    Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA

    It is known that a 1,2,3-triazolato-bridged dinuclear platinum(II) complex, [{cis-Pt(NH3)2}2(µ-OH)(µ-1,2,3-ta-N 1,N 2)](NO3)2 (AMTA), shows high in vitro cytotoxici...

    Naoko Kida, Yousuke Katsuda, Yuko Yoshikawa… in JBIC Journal of Biological Inorganic Chemi… (2010)

  9. No Access

    Article

    The role of the retrograde colonic enema in children with spina bifida: is it inferior to the antegrade continence enema?

    The aim of this study was to evaluate the efficacy of the retrograde colonic enema relative to the Malone antegrade continence enema.

    Daisuke Matsuno, Yuichiro Yamazaki… in Pediatric Surgery International (2010)

  10. No Access

    Article

    Chemiluminescence on a Microchip

    **ng-Zheng Wu, Mari Suzuki, Tsuguo Sawada, Takehiko Kitamori in Analytical Sciences (2000)