6 Result(s)
within
Mariëlle C. Haks
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Open AccessTuberculosis causes highly conserved metabolic changes in human patients, mycobacteria-infected mice and zebrafish larvae
Tuberculosis is a highly infectious and potentially fatal disease accompanied by wasting symptoms, which cause severe metabolic changes in infected people. In this study we have compared the effect of mycobacteri...
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Article
Open AccessAnalyzing the impact of Mycobacterium tuberculosis infection on primary human macrophages by combined exploratory and targeted metabolomics
The pathogenic success of Mycobacterium tuberculosis (Mtb) is tightly linked to its ability to recalibrate host metabolic processes in infected host macrophages. Since changes in cellular metabolic intermediates ...
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Article
Open AccessWhole blood RNA signatures in leprosy patients identify reversal reactions before clinical onset: a prospective, multicenter study
Early diagnosis of leprosy is challenging, particularly its inflammatory reactions, the major cause of irreversible neuropathy in leprosy. Current diagnostics cannot identify which patients are at risk of deve...
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Article
Open AccessWhole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites
A highly effective vaccine that confers sterile protection to malaria is urgently needed. Immunization under chemoprophylaxis with sporozoites (CPS) consistently confers high levels of protection in the Contro...
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Article
Open AccessCombined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials
Antibiotic resistance poses rapidly increasing global problems in combatting multidrug-resistant (MDR) infectious diseases like MDR tuberculosis, prompting for novel approaches including host-directed therapie...
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Article
Open AccessTranscriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria
Identifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retr...
