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Article
Open AccessMetabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas
T cell-based immunotherapies have exhibited promising outcomes in tumor control; however, their efficacy is limited in immune-excluded tumors. Cancer-associated fibroblasts (CAFs) play a pivotal role in shapin...
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Article
Open AccessCombined PD-L1/TGFβ blockade allows expansion and differentiation of stem cell-like CD8 T cells in immune excluded tumors
TGFβ signaling is associated with non-response to immune checkpoint blockade in patients with advanced cancers, particularly in the immune-excluded phenotype. While previous work demonstrates that converting t...
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Chapter and Conference Paper
Robotic Systems as a Part of AI Fundamentals Course at ITS Academy Foundation for New Life Technologies n.a. Alessandro Volta in Trieste, Italy
The healthcare sector has always been the crucible for a high level of technology, as its use has a direct impact on life expectancy and the probability of recovery from a disease. In Italy the ITS Academy Founda...
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Article
Open AccesscircCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by sha** the immune microenvironment
Exonic circular RNAs (circRNAs) produce predominantly non-coding RNA species that have been recently profiled in many tumors. However, their functional contribution to cancer progression is still poorly unders...
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Article
Open AccessSingle cell-derived spheroids capture the self-renewing subpopulations of metastatic ovarian cancer
High Grade Serous Ovarian cancer (HGSOC) is a major unmet need in oncology, due to its precocious dissemination and the lack of meaningful human models for the investigation of disease pathogenesis in a patien...
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Article
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression
Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and metastatic colorectal cancer and n...
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Article
Open AccessEpigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically charac...
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Chapter
Codes and Structures in Landscape: The Normative Superstructure and the Difficult Whole of Signs and Significance
The ten topics posed by Venturi evidently overcome a purely formal evaluation and should be considered as topics of semiotic research. As such they can therefore be read in terms of structures and codes; compl...
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Article
p63 is a cereblon substrate involved in thalidomide teratogenicity
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic and antimyeloma activities. CRBN functions as a substrate receptor of the E3 ubiqu...
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Protocol
Chromium 10× Single-Cell 3′ mRNA Sequencing of Tumor-Infiltrating Lymphocytes
Chromium 10× 3′ V2 protocol is a 3′ end counting single-cell mRNA sequencing protocol that allows to process and sequence RNA from thousands of cells in parallel. Chromium10× by 10× Genomics is an emulsion-bas...
