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Article
Open AccessAuthor Correction: scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
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Article
Open AccessscCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
Extrachromosomal circular DNAs (eccDNAs) have emerged as important intra-cellular mobile genetic elements that affect gene copy number and exert in trans regulatory roles within the cell nucleus. Here, we desc...
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Article
Open AccessTissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
The process in which locally confined epithelial malignancies progressively evolve into invasive cancers is often promoted by unjamming, a phase transition from a solid-like to a liquid-like state, which occur...
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Article
Open AccessAuthor Correction: Tissue fluidification promotes a cGAS–STING cytosolic DNA response in invasive breast cancer
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Protocol
Establishment and Maintenance of Human CRC-Derived Organoids for PcG Studies
In the recent years, the establishment of self-organizing 3D cultures (organoids) generated from human primary tissues added a novel and physiological viewpoint to interrogate basic and pathological matters. I...
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Article
Clonally expanded EOMES+ Tr1-like cells in primary and metastatic tumors are associated with disease progression
Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and metastatic colorectal cancer and n...
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Article
Open AccessEpigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ
Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically charac...
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Article
Open AccessNaturally C-Terminally truncated STAT5 (STAT5Δ): a novel negative controller of HIV-1 transcription and expression
