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Open AccessFerroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury
We show that redox active iron can induce a regulated form of non-apoptotic cell death and tissue damage called ferroptosis that can contribute to secondary damage and functional loss in the acute and chronic ...
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Article
Open AccessInhibition of the Nogo-pathway in experimental spinal cord injury: a meta-analysis of 76 experimental treatments
Recovery after spinal cord injury (SCI) may be propagated by plasticity-enhancing treatments. The myelin-associated nerve outgrowth inhibitor Nogo-A (Reticulon 4, RTN4) pathway has been shown to restrict neuro...
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Publisher Correction: The neuroanatomical–functional paradox in spinal cord injury
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Open AccessSpinal infection with intraspinal abscess or empyema and acute myelopathy: comparative analysis of diagnostics, therapy, complications and outcome in primary care
This study on pyogenic spinal infections with intraspinal epidural involvement (PSI +) compared the outcome of patients with spinal cord injury (SCI) to those without (noSCI) taking diagnostic algorithm, thera...
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Open AccessBaseline predictors of in-hospital mortality after acute traumatic spinal cord injury: data from a level I trauma center
Comorbidity scores are important predictors of in-hospital mortality after traumatic spinal cord injury (tSCI), but the impact of specific pre-existing diseases is unknown. This retrospective cohort study aims...
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Open AccessAssociation of age with the timing of acute spine surgery–effects on neurological outcome after traumatic spinal cord injury
To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI).
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Article
The neuroanatomical–functional paradox in spinal cord injury
Although lesion size is widely considered to be the most reliable predictor of outcome after CNS injury, lesions of comparable size can produce vastly different magnitudes of functional impairment and subseque...
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Open AccessClinical decision-making on spinal cord injury-associated pneumonia: a nationwide survey in Germany
Survey study.
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Open AccessEffects of local hypothermia–rewarming on physiology, metabolism and inflammation of acutely injured human spinal cord
In five patients with acute, severe thoracic traumatic spinal cord injuries (TSCIs), American spinal injuries association Impairment Scale (AIS) grades A–C, we induced cord hypothermia (33 °C) then rewarming (...
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Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex
Spinal cord injury causes life-threatening infections. The authors report that this is partially mediated by a maladaptive neuroendocrine reflex, extending from the spinal cord to the adrenal glands, where it ...
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Open AccessAcute transient spinal paralysis and cardiac symptoms following an accidental epidural potassium infusion – a case report
To describe a case of an accidental epidural potassium infusion leading to an acute transient spinal paralysis and cardiac symptoms and review the literature on that topic.
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Open AccessNatural Killer (NK) Cell Functionality after human Spinal Cord Injury (SCI): protocol of a prospective, longitudinal study
Natural killer (NK) cells comprise the main components of lymphocyte-mediated nonspecific immunity. Through their effector function they play a crucial role combating bacterial and viral challenges. They are a...
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Open AccessThe SCIentinel study - prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS) - study protocol and interim feasibility data
Infections are the leading cause of death in the acute phase following spinal cord injury and qualify as independent risk factor for poor neurological outcome (“disease modifying factor”). The enhanced suscept...
