4 Result(s)
within
English
Science, Humanities and Social Sciences, multidisciplinary
Marc R. Friedländer
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Article
Open AccessSequence variation between 462 human individuals fine-tunes functional sites of RNA processing
Recent advances in the cost-efficiency of sequencing technologies enabled the combined DNA- and RNA-sequencing of human individuals at the population-scale, making genome-wide investigations of the inter-indiv...
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Article
Open AccessSignatures of positive selection reveal a universal role of chromatin modifiers as cancer driver genes
Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which fuels tumor heterogeneity and ultimately complicates cancer driver gene identification. Here, we integrate c...
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Article
Open AccessEXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
The exosome is a ribonucleolytic complex that plays important roles in RNA metabolism. Here we show that the exosome is necessary for the repair of DNA double-strand breaks (DSBs) in human cells and that RNA c...
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Article
Open AccessNuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
Single-cell RNA sequencing studies on gene co-expression patterns could yield important regulatory and functional insights, but have so far been limited by the confounding effects of differentiation and cell c...
