8 Result(s)

Article

Specificity of serological screening tests and reference laboratory tests to diagnose gambiense human African trypanosomiasis: a prospective clinical performance study

Serological screening tests play a crucial role to diagnose gambiense human African trypanosomiasis (gHAT). Presently, they preselect individuals for microscopic confirmation, but in future “screen and treat” ...

Martial Kassi N’Djetchi, Oumou Camara, Mathurin Koffi… in Infectious Diseases of Poverty (2024)

Article

Publisher Correction: IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell… in Nature Communications (2024)

Article

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection

In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to be competent for forward transmission. The interaction between parasites, adipose tissue, and the local immune s...

Matthew C. Sinton, Praveena R. G. Chandrasegaran, Paul Capewell… in Nature Communications (2023)

Article

Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study

Passive diagnosis of human African trypanosomiasis (HAT) at the health facility level is a major component of HAT control in Guinea. We examined which clinical signs and symptoms are associated with HAT, and a...

Oumou Camara, Mamadou Camara, Laura Cristina Falzon… in Infectious Diseases of Poverty (2023)

Article

Implications of asymptomatic infection for the natural history of selected parasitic tropical diseases

Progress has been made in the control or elimination of tropical diseases, with a significant reduction of incidence. However, there is a risk of re-emergence if the factors fueling transmission are not dealt ...

Jorge Alvar, Fabiana Alves, Bruno Bucheton, Louise Burrows… in Seminars in Immunopathology (2020)

Article

Copy number variation in human genomes from three major ethno-linguistic groups in Africa

Copy number variation is an important class of genomic variation that has been reported in 75% of the human genome. However, it is underreported in African populations. Copy number variants (CNVs) could have i...

Oscar A. Nyangiri, Harry Noyes, Julius Mulindwa, Hamidou Ilboudo… in BMC Genomics (2020)

Article

Identification of a Tsal1_52–75 salivary synthetic peptide to monitor cattle exposure to tsetse flies

The saliva of tsetse flies contains a cocktail of bioactive molecules inducing specific antibody responses in hosts exposed to bites. We have previously shown that an indirect-ELISA test using whole salivary e...

Martin Bienvenu Somda, Sylvie Cornelie, Zakaria Bengaly… in Parasites & Vectors (2016)

Article

Evaluating long-term effectiveness of slee** sickness control measures in Guinea

Human African Trypanosomiasis threatens human health across Africa. The subspecies T.b. gambiense is responsible for the vast majority of reported HAT cases. Over the past decade, expanded control efforts accompl...

Abhishek Pandey, Katherine E. Atkins, Bruno Bucheton, Mamadou Camara… in Parasites & Vectors (2015)