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Article
Three-year outcomes of preoperative chemoradiotherapy plus nivolumab in microsatellite stable and microsatellite instability-high locally advanced rectal cancer
Preoperative chemoradiotherapy (CRT) followed by surgery is the standard treatment for locally advanced rectal cancer (LARC). We reported the short-term outcomes of the VOLTAGE trial that investigated the safe...
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Article
Open AccessSalvage surgery for pouch-related complication after ileal pouch–anal anastomosis: a report of two cases
Pouch-related complications (PRCs), such as pelvic abscesses and perianal complex fistulas, can occur after ileal pouch–anal anastomosis (IPAA) in ulcerative colitis (UC). They are often difficult to treat and...
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Article
Open AccessImpact of the endoscopic surgical skill qualification system on conversion to laparotomy after low anterior resection for rectal cancer in Japan (a secondary analysis of the EnSSURE study)
Conversion to laparotomy is among the serious intraoperative complications and carries an increased risk of postoperative complications. In this cohort study, we investigated whether or not the Endoscopic Surg...
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Article
Open AccessMetastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer
Circulating tumor cells (CTCs) play an important role in metastasis and recurrence. However, which cells comprise the complex tumor lineages in recurrence and are key in metastasis are unknown in colorectal ca...
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Article
Open AccessResection of anorectal fistula cancer associated with Crohn’s disease after preoperative chemoradiotherapy: a case report
Anorectal fistula cancer is often diagnosed in an advanced state, and radical resection is difficult when invasion of the pelvic wall is observed. In addition, there is currently no clear evidence for perioper...
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Article
A case of fulminant amoebic colitis during systemic chemotherapy for gastric cancer
Amoebiasis is a parasitic infection caused by the protozoan, Entamoeba histolytica. At times, amoebiasis is activated under immunosuppressive conditions such as chemotherapy. We report a case of fulminant amoe...
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Article
Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers
Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H) colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H CRCs is generated in cancer evolution and how...
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Article
Open AccessPan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis
Integrating genomic data of multiple cancers allows de novo cancer grou** and elucidating the shared genetic basis across cancers. Here, we conduct the pan-cancer and cross-population genome-wide association...
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Article
Open AccessTesticular metastasis 9 years after resection of primary descending colon cancer with simultaneous pulmonary metastasis: a case report
Metastatic testicular cancer is rare. In particular, primary colorectal cancer rarely metastasizes to the testes. This study reports a case of testicular metastasis recurrence 9 years after the resection of a ...
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Article
Open AccessCancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also in many cancers. Tumour-infiltrating CD103+ Trm cells predominantly co...
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Article
Open AccessPhase II dose titration study of regorafenib in progressive unresectable metastatic colorectal cancer
Regorafenib has shown significant survival benefit as a salvage therapy for colorectal cancer; however, its starting dose has been controversial in recent studies. Therefore, we conducted a prospective study o...
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Article
Open AccessTumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer
Approximately 10% of patients with colorectal cancer with submucosal invasion have lymph node metastasis. Pathological risk factors for lymph node metastasis have varying sensitivities and specificities. To pr...
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Article
Three-dimensional anatomical structure formed by granule cell layer and pyramidal cell layer in human hippocampus
In the human hippocampus, the pyramidal layer consists of the inferior aspect of the hippocampus which is organized segmentally. Each segment, together with granule layer of the dentate gyrus, exhibits structu...
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Article
Postoperative pain management after concomitant sacrectomy for locally recurrent rectal cancer
To assess pain management in patients post-sacrectomy, focusing on opioid use, and to identify the factors associated with postoperative pain.
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Article
Risk factors for postoperative proximal deep vein thrombosis and pulmonary embolism after laparoscopic colorectal cancer surgery: analysis of a multicenter randomized controlled trial
Postoperative venous thromboembolism (VTE) is a major and potentially fatal postoperative complication of colorectal cancer surgery. However, there is uncertainty about the necessity for anticoagulant prophyla...
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Article
Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease
The intestinal environment plays important roles in mucosal barrier homeostasis and intestinal inflammation, as clarified in studies using experimental animals but not in humans.
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Article
Open AccessLocally advanced rectal cancer receiving total neoadjuvant therapy combined with nivolumab: a case report and literature review
The standard treatment for locally advanced rectal cancer (LARC) is preoperative chemoradiotherapy (CRT) followed by surgery and adjuvant chemotherapy. However, it has been suggested that intensification of ne...
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Article
Open AccessDevelopment and evaluation of a Japanese prediction model for low anterior resection syndrome after rectal cancer surgery
Low anterior resection syndrome (LARS) is the most common complication after rectal cancer resection. We aimed to identify LARS' predictive factors and construct and evaluate a predictive model for LARS.
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Article
The prediction of postoperative anorectal dysfunction after low anterior resection for lower rectal cancer by measuring the volume of defecation-related muscles
Approximately 90% of patients are thought to develop bowel dysfunction after low anterior resection (LAR). Although some prognostic factors have been reported, the volumes of defecation-related muscles have no...
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Article
Open AccessA stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells
KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome st...
