8 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
Makoto Suzuki
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Article
Open AccessRisk prediction of inappropriate implantable cardioverter-defibrillator therapy using machine learning
We aimed to develop machine learning-based predictive models for identifying inappropriate implantable cardioverter-defibrillator (ICD) therapy. Our study included 182 consecutive cases (average age 62.2 ± 4.5...
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Article
Open AccessIdentification of tumor-related genes via RNA sequencing of tumor tissues in Xenopus tropicalis
Cancer treatment is still challenging because the disease is often caused by multiple mutations. Although genomic studies have identified many oncogenes and tumor suppressor genes, gene sets involved in tumori...
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Article
Open AccessEvaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
With recent advances in immune checkpoint inhibitors (ICIs), immunotherapy has become the standard treatment for various malignant tumors. Their indications and dosages have been determined empirically, taking...
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Article
Open AccessAssessment of the VDW interaction converting DMAPS from the thermal-motion form to the hydrogen-bonded form
Assessment of van der Waals (VDW) interactions is fundamental to all of the central quest of structure that regulates the biological function. VDW interactions contributing to intramolecular weak hydrogen bond...
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Article
Open AccessFast and effective mitochondrial delivery of ω-Rhodamine-B-polysulfobetaine-PEG copolymers
Mitochondrial targeting and entry, two crucial steps in fighting severe diseases resulting from mitochondria dysfunction, pose important challenges in current nanomedicine. Cell-penetrating peptides or targeti...
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Article
Open AccessInsights into the Transcriptional Architecture of Behavioral Plasticity in the Honey Bee Apis mellifera
Honey bee colonies exhibit an age-related division of labor, with worker bees performing discrete sets of behaviors throughout their lifespan. These behavioral states are associated with distinct brain transcr...
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Chapter
The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4
Transient receptor potential vanilloid 4 (TRPV4) is a member of the TRP family of channels. It contains 6 transmembrane domains and was first identified as a hypoosmolality-activated Ca2+ permeable channel. TRPV4...
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Article
Cloning of a pH-sensitive K+ channel possessing two transmembrane segments
THE mammalian renal collecting ducts are responsible for secreting potassium ions into the urine and are a major regulatory site for potassium homeostasis1, in which a voltage-independent pH-sensitive K+ channel ...
