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Article
5th Japanese Association of Hepato-Biliary-Pancreatic Surgery
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Article
How I do it — Necrosectomy in acute pancreatitis. Open drainage with diverting ileostomy for acute necrotizing pancreatitis
Infected pancreatic necrosis which spreads extensively in the retroperitoneal space requires open drainage to prevent the formation of residual abscess. With open drainage and repeated debridement, we often en...
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Article
Strategy for treatment of acute necrotizing pancreatitis: Importance of continuous regional arterial infusion of protease inhibitor and antibiotics in the early phase
A new strategy for the treatment of acute necrotizing pancreatitis (ANP) is reported. In this prospective study, all patients received intensive medical support. Surgery was performed in patients with infected...
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Chapter and Conference Paper
A Comparison of Quality of Life: Standard Versus Pylorus-Preserving Pancreatoduodenectomy
Pylorus-preserving pancreatoduodenectomy (PPPD) has been adopted for patients with disease of the periampullary region as an alternative to the standard pancreatoduodenectomy. To qualify the exact effect of PP...
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Article
Mucin-producing tumor of the pancreas — surgical treatment
To evaluate appropriate surgical treatment and to predict prognosis for mucin-producing tumors (MPTs) of the pancreas, we conducted a retrospective clinicopathological study in 25 patients with MPT. Eight pati...
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Article
Pancreatic microcirculation in acute pancreatitis
We present a review of the microvascular morphology of the pancreas and microstructure of the pancreatic lobule, and report our experimental results of the investigation of pancreatic microcirculation followi...
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Article
Intraoperative radiotherapy for pancreatic adenocarcinoma
Intraoperative radiotherapy (IORT) is an innovative treatment approach for cancer of the pancreas. The common causes of treatment failure in pancreatic cancer are regional recurrence and distant metastasis. W...
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Article
Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22–q24.1 in human pancreatic ductal adenocarcinoma
Background. Recently, a human G/T-specific TDG gene was identified. This protein acts in a system correcting G/T mispairs to G/C pairs. TDG was mapped to chromosome bands 12q22–q24.1, one of the ...
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Article
Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection
Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blo...
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Chapter and Conference Paper
Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells
Some reports suggest that cancer patients have a better prognosis when dendritic cells (DCs) infiltrate their tumors. Although the role of these DCs is not fully understood, we focused on a potential effector ...
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Chapter and Conference Paper
Controlling Tumor Microenvironment by the Antiangiogenesis Strategy
Angiogenesis occurs when the balance between negative and positive regulators inclines toward the latter, allowing the tumor and metastases to develop. Studies have found that genetic alterations may correlate...
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Article
Early Microcirculatory Derangement in Mild and Severe Pancreatitis Models in Mice
An in vivo microscopic technique was used to clarify the increase in microvascular permeability and enhanced leukocyte–endothelium interaction of pancreatic microcirculation in experimental pancreatitis of di...
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Article
Cytokine modulation in acute pancreatitis
The clinical manifestations of acute pancreatitis (AP) vary significantly from mild to lethal in form, the severity of the disease being largely determined by the actions of various kinds of inflammatory medi...
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Chapter
Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells
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Article
Gene therapy for pancreatic cancer based on genetic characterization of the disease
In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we analyzed the association of loss of heterozygosity (LOH) with the clinicopathological features of the disease....
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Article
Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus
In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we examined the genetic alternations of pancreatic cancer. Based on these results, we are develo** a new gene th...
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Article
Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer
Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, ...
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Article
Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells
SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-β)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4...
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Article
Abrogation of DUSP6 by hypermethylation in human pancreatic cancer
Our previous study indicated that DUSP6/MKP-3/PYST1 could act as a tumor suppressor in human pancreatic cancer. DUSP6 was frequently underexpressed in primary pancreatic cancer tissues by an unknown mechanism....
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Article
Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study
Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological...
