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  1. No Access

    Article

    Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer

    Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, ...

    Makoto Sunamura, Dan G. Duda, Maivel H. Ghattas, Lucian Lozonschi… in Angiogenesis (2003)

  2. No Access

    Article

    Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells

    SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-β)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4...

    Dan G Duda, Makoto Sunamura, Liviu P Lefter, Toru Furukawa, Tadaaki Yokoyama… in Oncogene (2003)

  3. No Access

    Article

    Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus

    In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we examined the genetic alternations of pancreatic cancer. Based on these results, we are develo** a new gene th...

    Makoto Sunamura, Masaru Oonuma, Fuyuhiko Motoi, Hisashi Abe, Yukoh Saitoh… in Human Cell (2002)