15 Result(s)
within
MARIA PELLEGRINI
Life Sciences
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Chapter
Secondary and tertiary fold of the human parathyroid hormone1–34 in different environments as a pathway to bioactive conformation
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Chapter
Lactam cyclization [i to (i+4)] for nucleation/stabilization of α-helices?
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Chapter
RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity
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Chapter
CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology
The peptide hormone calcitonin (CT) acts through its G-protein coupled receptor to reduce serum calcium levels by inhibiting bone resorption and promoting renal calcium excretion. In addition, CT modulates the...
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Chapter
Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane
We have previously described the structural features of parathyroid hormone (PTH) as determined by high-resolution NMR under a number of different conditions, including the membrane mimetic environment of dode...
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Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK1 and CCK2: An NMR-Based Study
Cholecystokinin (CCK) is a peptide hormone and neurotransmitter involved in a number of physiological processes of the gall bladder and pancreas, in the gastrointestinal tract, and anxiety, memory, and analges...
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Article
Conformational investigation of a novel dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
Conformational investigation of a novel, dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
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Article
Serum, insulin and phorbol esters stimulate rRNA and tRNA gene expression in both dividing and nondividing Drosophila cells
The expression of genes that code for the large ribosomal RNAs (rRNAs) and tRNAs can be regulated by calcium, serum, insulin and a tumor-promoting phorbol ester, TPA. These effectors can rapidly alter rRNA and...
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Chapter
Serum, insulin and phorbol esters stimulate rRNA and tRNA gene expression in both dividing and nondividing Drosophila cells
The expression of genes that code for the large ribosomal RNAs (rRNAs) and tRNAs can be regulated by calcium, serum, insulin and a tumor-promoting phorbol ester, TPA. These effectors can rapidly alter rRNA and...
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Article
Identification of proteins at the peptidyl-tRNA binding site of rat liver ribosomes
We have identified proteins involved in the peptidyl-tRNA-binding site of rat liver ribosomes, using an affinity label designed specifically to probe the P-site in eukaryotic peptidyl transferase. The label is...
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Article
DNA sequence organization in soybean investigated by electron microscopy
An electron microscopic analysis of the DNA sequence organization in the soybean genome is reported. This analysis employed the gene 32 proteinethidium bromide spreading technique, a procedure which produces s...
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Article
A new method of in situ hybridization
A new method for gene map** at the chromosome level using in situ hybridization and scanning electron microscopy is described and has been applied to map** the rRNA genes of Drosophila melanogaster. Biotin is...
