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Article
Open AccessS1 guidelines “lumbar puncture and cerebrospinal fluid analysis” (abridged and translated version)
Cerebrospinal fluid (CSF) analysis is important for detecting inflammation of the nervous system and the meninges, bleeding in the area of the subarachnoid space that may not be visualized by imaging, and the ...
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Article
S1-Leitlinie: Lumbalpunktion und Liquordiagnostik
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Article
Stellenwert der Liquordiagnostik bei neuropsychiatrischen Erkrankungen
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Article
Open AccessRNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response
Response to antidepressant treatment is highly variable with some patients responding within a few weeks, whereas others have to wait for months until the onset of clinical effects. Gene expression profiling m...
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Article
The effect of the ANKK1/DRD2 Taq1A polymorphism on weight changes of dopaminergic treatment in prolactinomas
Treatment with dopamine agonists in patients with prolactinomas has been associated with weight loss in short term studies. However, long-term studies on weight changes are lacking. Taq1A is a restriction fragmen...
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Article
Open AccessConvergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response
Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful so far. Here we present a translational approach ...
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Article
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-β therapy in multiple sclerosis patients
Interferons-β (IFN-β) are the most widely used immunomodulatory drugs for treatment of multiple sclerosis (MS). The development of neutralizing antibodies (NABs) against IFN-β is one of the main reasons for tr...
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Article
TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
The lifetime prevalence of panic disorder (PD) is up to 4% worldwide and there is substantial evidence that genetic factors contribute to the development of PD. Single-nucleotide polymorphisms (SNPs) in TMEM13...
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Article
Erratum: Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
Correction to: Molecular Psychiatry (2010) 15, 736–747; advance online publication 6 January 2009; doi: 10.1038/mp.2008.142 Following the online publication of the above article, the authors noted that the wro...
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Article
Liquordiagnostik bei CT-negativer Subarachnoidalblutung
Die Diagnostik CT-negativer Subarachnoidalblutungen (SAB) stellt eine besondere klinische Herausforderung dar. Die Lumbalpunktion mit Liquordiagnostik ist hierbei die diagnostische Methode der Wahl. Die Diagno...
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Article
Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
Major depression and the metabolic syndrome (MetS) are interacting clinical conditions influenced by genetic susceptibility. For both disorders, impaired serotonergic neurotransmission in specific brain areas ...
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Article
Open AccessThe GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
Recent evidence suggests that the GABA transporter 1 (GAT-1; SLC6A1) plays a role in the pathophysiology and treatment of anxiety disorders. In order to understand the impact of genetic variation within SLC6A1...
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Article
Evidence for associations between PDE4D polymorphisms and a subtype of neuroticism
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Article
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
Multiple sclerosis (MS) is the most common chronic inflammatory neurologic disorder diagnosed in young adults and, due to its chronic course, is responsible for a substantial economic burden. MS is considered ...
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Article
Association of polymorphisms in the angiotensin-converting enzyme gene with syndromal panic attacks
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Article
Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
Angiotensin-converting enzyme (ACE) is assumed to influence the activity of the hypothalamic-pituitary-adrenocortical (HPA) system, which shows hyperactivity in the majority of patients with major depression. ...
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Article
Proteomic analysis of the CSF in unmedicated patients with major depressive disorder reveals alterations in suicide attempters
This is the first report on proteomic analysis of the cerebrospinal fluid (CSF) in unmedicated suicide attempters and non-attempters with major depressive disorder.Two-dimensional (2D) gel electrophoresis reve...
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Article
Pharmacological and Nonpharmacological Factors Influencing Hypothalamic–Pituitary–Adrenocortical Axis Reactivity in Acutely Depressed Psychiatric In-patients, Measured by the Dex-CRH Test
The most consistent biological findings in patients with depression are abnormalities in the hypothalamic–pituitary–adrenal (HPA)-axis, which can be measured using the combined dexamethasone-suppression/CRH-st...
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Chapter and Conference Paper
Aromatic alcohols as neuroprotectants
Free radicals and oxidative stress-induced neuronal cell death have been implicated in various neurological disorders including neurodegenerative diseases. We have recently shown that estrogens can protect neu...
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Chapter and Conference Paper
Cytoplasmatic Expression of CD34 in Acute Leukemia
CD34 is preferentially expressed on immature haematopoietic cells and also in transformed haematopoietic cells. Here we tested the surface (s) and cytoplasmatic (c) CD34 expression on bone marrow blasts in twe...
