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Open AccessVenlafaxine’s therapeutic reference range in the treatment of depression revised: a systematic review and meta-analysis
The selective serotonin and norepinephrine reuptake inhibitor venlafaxine is among the most prescribed antidepressant drugs worldwide and, according to guidelines, its dose titration should be guided by drug-l...
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Article
Pharmakogenetik in der Psychiatrie: eine Standortbestimmung
In der vorliegenden Arbeit aus dem Referat Neurobiologie und Genetik der Deutschen Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN) wird der Stand der Literatur zur Be...
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Open AccessIntervention with a caspase-1 inhibitor reduces obesity-associated hyperinsulinemia, non-alcoholic steatohepatitis and hepatic fibrosis in LDLR−/−.Leiden mice
Non-alcoholic steatohepatitis (NASH) is a serious liver condition, closely associated with obesity and insulin resistance. Recent studies have suggested an important role for inflammasome/caspase-1 in the deve...
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Open AccessConvergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response
Despite the overt need for improved treatment modalities in depression, efforts to develop conceptually novel antidepressants have been relatively unsuccessful so far. Here we present a translational approach ...
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Article
Pädiatrische Schmerztherapie
Eine Grundvoraussetzung für ein erfolgreiches Schmerzmanagement ist ein umfassendes Wissen über die moderne Schmerztherapie und dessen Umsetzung in den klinischen Alltag. Im Bereich der Pädiatrie ist bis dato ...
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Erratum: Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
Correction to: Molecular Psychiatry (2010) 15, 736–747; advance online publication 6 January 2009; doi: 10.1038/mp.2008.142 Following the online publication of the above article, the authors noted that the wro...
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Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
Major depression and the metabolic syndrome (MetS) are interacting clinical conditions influenced by genetic susceptibility. For both disorders, impaired serotonergic neurotransmission in specific brain areas ...
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Article
Deutscher Schmerzfragebogen für Kinder, Jugendliche und deren Eltern (DSF-KJ)
Eine multidimensionale Erfassung chronischer Schmerzen stellt das wichtigste Instrument für die Diagnostik und Therapie von chronischen Schmerzen dar. Während im Erwachsenenbereich der Deutsche Schmerzfragebog...
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Open AccessSpecific effects of Lef-1 splice variants on the regulation of gene expression in pancreatic cancer cells
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Arbeitsgebiete der Kinderkrankenpflege
In den Anfängen der beruflichen Kinderkrankenpflege hatten Kinderkrankenschwestern nur wenige Möglichkeiten der Schmerzbehandlung bei Kindern. Zudem wurden Schmerzen allgemein als unvermeidbar verstanden — „si...
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Article
Schmerzbezogene Co**strategien von Kindern und Jugendlichen mit chronischen Schmerzen
Validierte deutsche Co**-Messinstrumente für Kinder und Jugendliche mit chronischen Schmerzen sind rar. Anhand eines ambulanten Samples von 180 Kindern mit chronischen Schmerzen wurden eine Hauptkomponentena...
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Article
Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
Pancreatic cancer is a devastating disease with poor prognosis. Production of large quantities of extracellular matrix and early metastasis are characteristics of this disease. One important step in the develo...
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Wilms' tumour gene 1 (WT1) in human neoplasia
The transcription factor Wilms' tumour gene 1 (WT1) is important as a prognostic marker as well as in the detection and monitoring of minimal residual disease in leukaemia and myelodysplastic syndromes. Eviden...
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Palliativversorgung von Kindern in Deutschland
In Deutschland existiert keine Kinderpalliativstation. Dabei könnten dort tätige Kinderpalliativmediziner ambulant niedergelassene Kinderärzte beraten, dort tätige Krankenschwestern könnten ambulante Kinderkran...
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Open AccessExpression of MTA1 promotes motility and invasiveness of PANC-1 pancreatic carcinoma cells
The human metastasis-associated protein 1 (MTA1) is a constituent of the nucleosome-remodelling and -deacetylation complex. Its expression has been correlated with the invasion and metastasis of epithelial neo...
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Increase of inactive intra-alveolar surfactant subtypes in lungs of asthmatic Brown Norway rats
We tested the hypothesis whether allergic airway inflammation in ovalbumin sensitized and challenged Brown Norway rats is associated with intrinsic surfactant alteration and dysfunction. The determination of ...
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Article
TGFβ1 represses proliferation of pancreatic carcinoma cells which correlates with Smad4-independent inhibition of ERK activation
Transforming growth factor beta (TGFβ) is a tumor suppressor acting as inhibitor of cell cycle progression of epithelial cells. We show that treatment of the pancreatic carcinoma cell lines PANC-1 and BxPC-3 w...
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Mechanisms of Fibrosis and Potential Antifibrotic Agents
Fibrosis is a pathological process resulting from injury and can occur in any organ. The biological cause of fibrosis is the accumulation of excessive amounts of extracellular matrix, leading to tissue dysfunc...
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Article
Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse
HUMAN X-linked Duchenne and Becker muscular dystrophies are due to defects in dystrophin, the product of an exceptionally large gene1,2. Although dystrophin has been characterized as a spectrin-like3 submembranou...
