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Article
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (CD), underpinned by a known unbalance between microbiota, IP and immune respo...
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Article
Open AccessCoincident onset of multiple sclerosis and Herpes simplex virus 1 encephalitis: a case report
Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis. Howev...
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Article
Use of herbal remedies by multiple sclerosis patients: a nation-wide survey in Italy
Though recent progress in multiple sclerosis (MS) treatment is remarkable, numerous unmet needs remain to be addressed often inducing patients to look for complementary and alternative medicines (CAM), especia...
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Article
Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation
Frontotemporal dementia (FTD) is one of the most important neurodegenerative conditions and Granulin (GRN) is one of the major genes associated to the disease. FTD-GRN patients are still orphan for any evidence-b...
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Article
Quality of life of multiple sclerosis patients with comorbid migraine
The aim of the present study was to investigate the impact of comorbid migraine on quality of life (QoL) of patients with multiple sclerosis (MS). Forty-four MS patients with comorbid migraine and 44 sex/age-m...
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Article
Multiple sclerosis: pharmacogenomics and personalised drug treatment
Multiple sclerosis (MS) is a disorder of the central nervous system with an inflammatory and a neurodegenerative component. We do not yet have a definitive therapy for MS. Attempts to develop new treatments ar...
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Article
Physiopathology of multiple sclerosis
Pleiotropy and redundancy are distinctive elements of the immune response. Recent research into the inflammatory component of multiple sclerosis (MS) indicates that, as expected, pleiotropy and redundancy char...
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Article
The effect of Bacille Calmette-Guérin on the evolution of new enhancing lesions to hypointense T1 lesions in relapsing remitting MS
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Chapter and Conference Paper
Immune activation in the interface between innate immunity and adaptive response:in vitro studies and therapeutical implications
In multiple sclerosis (MS), as well as in other putatively T cell mediated diseases, much attention has been devoted to possible dysregulations at the level of the adaptive immune response, with particular emp...
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Chapter
Non-Myelin Antigen Autoreactivity in Multiple Sclerosis
Immune-mediated damage is probably the most relevant event among those that contribute to the pathogenesis of multiple sclerosis (MS). The search for autoantigens inducing T cell responses in MS as well as in ...
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Article
Four-year follow-up of a case of acute multiple sclerosis of the Marburg type
We describe the clinical course, treatment and magnetic resonance findings during a four-year follow-up of a patient with acute multiple sclerosis of the Marburg type, treated with steroid and mannitol therapy...
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Article
Target epitopes of myelin basic protein specific T cell lines in multiple sclerosis
A highly efficient new method for the generation of antigen specific T cell lines (TCL) is now available. By this method we established 134 myelin basic protein (MBP) TCL from the peripheral blood of 9 patient...
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Article
Multiple sclerosis and HTLV retroviruses