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Open AccessIntermediate dose enoxaparin in hospitalized patients with moderate-severe COVID-19: a pilot phase II single-arm study, INHIXACOVID19
Randomized clinical trials in non-critically ill COVID-19 patients showed that therapeutic-dose heparin increased survival with reduced organ support as compared with usual-care thromboprophylaxis, albeit with...
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Hyperuricemia and Risk of Cardiovascular Outcomes: The Experience of the URRAH (Uric Acid Right for Heart Health) Project
The latest European Guidelines of Arterial Hypertension have officially introduced uric acid evaluation among the cardiovascular risk factors that should be evaluated in order to stratify patient’s risk. In fa...
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Article
Intestinal Permeability in Relapsing-Remitting Multiple Sclerosis
Changes of intestinal permeability (IP) have been extensively investigated in inflammatory bowel diseases (IBD) and celiac disease (CD), underpinned by a known unbalance between microbiota, IP and immune respo...
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Article
Open AccessCoincident onset of multiple sclerosis and Herpes simplex virus 1 encephalitis: a case report
Along with vitamin D, smoking, body mass index and others, Epstein Barr virus, other herpesviruses and human endogenous retroviruses represent plausible environmental risk factors for multiple sclerosis. Howev...
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Open AccessA staged screening of registered drugs highlights remyelinating drug candidates for clinical trials
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for t...
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Use of herbal remedies by multiple sclerosis patients: a nation-wide survey in Italy
Though recent progress in multiple sclerosis (MS) treatment is remarkable, numerous unmet needs remain to be addressed often inducing patients to look for complementary and alternative medicines (CAM), especia...
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Article
Open AccessP6.16 Left Ventricular Geometry and Carotid Vascular Damage in Patients Undergoing Coronary Angiography
Vascular structural(intima-media thickness, IMT) and functional(carotid stiffness, cPWV)alterations are related to different pattern of left ventricular (LV) geometry in general populations and in hypertensive...
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Open AccessP6.18 Cardiovascular Target Organ Damage in Premenopausal Systemic Lupus Erythematosus Patients and in Controls; Are There Any Differences?
In patients with Systemic lupus erythematosus (SLE) a greater prevalence of structural and functional cardiovascular (CV) alterations has been described, possibly explaining the higher incidence of CV events, ...
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Article
Attitudes and preferences for the clinical management of hypertension and hypertension-related cardiac disease in general practice: results of the Italian Hypertension and Heart Survey
The aim of this study was to evaluate attitudes and preferences for the clinical management of hypertensive patients with cardiac organ disease, including left ventricular hypertrophy (LVH) and coronary artery...
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Article
Results from a pilot study on amiodarone administration in monogenic frontotemporal dementia with granulin mutation
Frontotemporal dementia (FTD) is one of the most important neurodegenerative conditions and Granulin (GRN) is one of the major genes associated to the disease. FTD-GRN patients are still orphan for any evidence-b...
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P3.06: Assessment of Arterial Stiffness During a Five-Years Follow up in a General Population in Northern Italy
Carotid-femoral pulse wave velocity (cfPWV) is an independent predictor of cardiovascular events and its measurement is recommended by current hypertension guidelines. Few data are available on the progression...
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P3.29: Assessment of the Determinants of Local Carotid Stiffness in a General Population in Northern Italy
The determinants of aortic stiffness have been elucidated in several studies, while few data are available for carotid stiffness. Aim of the study was to identify the main determinants of carotid arterial stif...
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P1.16: Correlation Between Wall-To-Lumen Ratio of Retinal Arterioles and Clinic and 24 Hours Blood Pressure
Wall-to-lumen ratio of retinal arterioles might serve as an in-vivo parameter of vascular damage. Previous studies have shown a correlation between retinal arteriolar structure and blood pressure values, measu...
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Article
Open Access3.5 Effect of Short-Term Treatment with Lercanidipine on Circulating Endothelial Progenitor Cells and Structural Alterations in Retinal Arterioles
It has been previously demonstrated that dihydropyridine calcium channel blockers may possess antioxidant properties and might improve microvascular structure. The aim of the present study was therefore to inv...
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Book and Conference Proceedings
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Article
Open AccessP1.10: Prevalence of Resistant Hypertension in A General Population in Northern Italy: Associated Cardiovascular Risk Factors and Target Organ Damage
Resistant hypertension (RH) is defined by most guidelines as blood pressure that remains above goal despite use of at least 3 antihypertensive agents of different classes, including a diuretic, prescribed at o...
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Open AccessP2.07: Endothelium Dependent and Independent Dilatation in Different Vascular Beds
Objective Several methods have been proposed for the evaluation of endothelial dysfunction in patients with cardiovascular risk factors. Whether the flow-mediated dilation (FMD) in medium size arteries is rela...
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Article
Open Access7.3: Microcirculation Abnormalities as Related to Arterial Stiffness and Central Blood Pressure in Hypertensive Patients
The possible relationships between indicators of small resistance artery structure and of large artery distensibility have not yet been evaluated. Aim: to assess the relationship between carotido-femoral pulse...
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Article
Quality of life of multiple sclerosis patients with comorbid migraine
The aim of the present study was to investigate the impact of comorbid migraine on quality of life (QoL) of patients with multiple sclerosis (MS). Forty-four MS patients with comorbid migraine and 44 sex/age-m...
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Article
Open AccessP9.06 Serum Uric Acid Levels and Arterial Stiffness and Cardiac and Carotid Artery Structure in a General Population in Northern Italy
The relationship between serum uric acid (UA) levels and CV disease has been described since the late 19th century.The role of UA as an independent risk factor for CV events and its association with TOD is howeve...
