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Article
Open AccessClimate model selection via conformal clustering of spatial functional data
Climate model selection stands as a critical process in climate science and research. It involves choosing the most appropriate climate models to address specific research questions, simulating climate behavio...
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Article
Open AccessChlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2
Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome - only partially effective with current schemes - places this disease among the unmet medical needs, and effective ther...
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Article
Open AccessThe Molecular Tumor Board of the Regina Elena National Cancer Institute: from accrual to treatment in real-world
Molecular Tumor Boards (MTB) operating in real-world have generated limited consensus on good practices for accrual, actionable alteration map**, and outcome metrics. These topics are addressed herein in 124...
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Article
Pattern of care of brain tumor patients in the last months of life: analysis of a cohort of 3045 patients in the last 10 years
End-of-life in patients with brain cancer presents special challenges, and palliative care approach is underutilized. Patients with brain cancer, in the last months of life, receive frequent hospital readmissi...
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Article
Open AccessThe Glioma-IRE project − Molecular profiling in patients with glioma: steps toward an individualized diagnostic and therapeutic approach
This study aimed to characterize the genetic profile of patients with glioma and discuss the impact of next-generation sequencing in glioma diagnosis and treatment.
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Article
Open AccessA diagnostic circulating miRNA signature as orchestrator of cell invasion via TKS4/TKS5/EFHD2 modulation in human gliomas
Altered microRNA profiles have been observed not only in tumour tissues but also in biofluids, where they circulate in a stable form thus representing interesting biomarker candidates. This study aimed to iden...
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Article
Malignant meningioma mTOR mutated and precision medicine
WHO grade II and III meningiomas are more invasive than grade I malignancies and determine patients’ shorter overall survival. Their tendency to recur after treatment has represented an important therapeutic c...
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Article
Recurrent glioblastoma: which treatment? A real-world study from the Neuro-oncology Unit “Regina Elena” National Cancer Institute
The majority of patients with glioblastoma (GBM) experience disease progression. At recurrence, treatment options have limited efficacy. Many studies report a limited and short duration response rate. Although...
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Article
COV-BT Ire study: safety and efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with brain tumors
The BNT162b2 vaccine conferred 95% protection against COVID-19 in people aged 16 years or older.
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Article
Characterization and management of neurological adverse events during immune-checkpoint inhibitors treatment: an Italian multicentric experience
Neurological immune-related adverse events (nirAEs) are rare toxicities of immune-checkpoint inhibitors (ICI). With the increase of ICI oncological indications, their incidence is growing. Their recognition an...
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Article
Open AccessChlorpromazine induces cytotoxic autophagy in glioblastoma cells via endoplasmic reticulum stress and unfolded protein response
Glioblastoma (GBM; grade IV glioma) is characterized by a very short overall survival time and extremely low 5-year survival rates. We intend to promote experimental and clinical research on rationale and scie...
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Article
Clinical course of central nervous system demyelinating neurological adverse events associated with anti-TNF therapy
Previous studies have reported an association between anti-tumor necrosis factor alpha (anti-TNFα) treatment and central nervous system (CNS) events. We described eight patients presenting with demyelinating C...
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Article
Adjuvant chemotherapy after severe myelotoxicity during chemoradiation phase in malignant gliomas. Is it feasibile? Results from AINO study (Italian Association for Neuro-Oncology)
Malignant gliomas (MG) are aggressive brain tumours in adults. The standard of care is concurrent radiation plus temozolomide (TMZ) [chemo-radiotherapy (CRT)] followed by TMZ maintenance up to 6 months. TMZ is...
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Article
Selecting and correcting RCM models ensemble: a case study for the evaluation of thermal discomfort for the city of Prato
In this work we propose an approach for selecting a subset of regional climate models that have a reasonable skill in simulating the past climate and represent changes in average and extreme climatic condition...
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Article
Adult brainstem glioma: a multicentre retrospective analysis of 47 Italian patients
Adult brainstem gliomas are rare primary brain tumours with heterogeneous clinical course. The low frequency of these tumours makes it difficult to achieve high-quality evidence regarding prognostic factors, a...
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Article
Medulloblastoma of the adult: results from a multicenter retrospective study by AINO (Italian Association of Neuro-Oncology) and SIN (Italian Society of Neurology)
Medulloblastoma (MB) is the most common primary malignant intracranial tumor in childhood, but it is very rare in adults, and for this reason, the optimal treatment has not yet been defined. We designed a mult...
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Article
Open AccessRepurposing chlorpromazine in the treatment of glioblastoma multiforme: analysis of literature and forthcoming steps
Glioblastoma multiforme is a CNS cancer characterized by diffuse infiltrative growth, aggressive clinical behavior and very poor prognosis. The state-of-art clinical approach to this disease consists of surgic...
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Article
Correction to: Phase II study of weekly carboplatin in pretreated adult malignant gliomas
In the original article, the names of authors Mariantonia Carosi and Tatiana Koudriavtseva were incorrectly captured, and author Francesco Cognetti's affiliation was incorrect. The information is correctly sho...
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Article
Phase II study of weekly carboplatin in pretreated adult malignant gliomas
Patients with relapse of recurrent glioma have a poor outcome and limited treatment options. The aim of this study is to investigate the clinical benefit and tolerability of weekly intravenous administration o...
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Article
Vastus lateralis myofascial free flap for tongue reconstruction and hypoglossal-femoral anastomosis: neurophysiological study
Total or nearly glossectomy with laryngeal preservation may lead to development of dysfunction speech, chewing, and swallowing with orally disabled. Pellini et al. analyze the feasibility of vastus lateralis m...
