Intelligent Computing Methodologies
14th International Conference, ICIC 2018, Wuhan, China, August 15-18, 2018, Proceedings, Part III
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Article
The Role of HSP90 and TRAP1 Targets on Treatment in Hepatocellular Carcinoma
Hepatocellular Carcinoma (HCC) is the predominant form of liver cancer and arises due to dysregulation of the cell cycle control machinery. Heat Shock Protein 90 (HSP90) and mitochondrial HSP90, also referred ...
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DeepBSRPred: deep learning-based binding site residue prediction for proteins
Proteins–protein interactions (PPIs) are important to govern several cellular activities. Amino acid residues, which are located at the interface are known as the binding sites and the information about bindin...
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Protocol
Pairwise and Multi-chain Protein Docking Enhanced Using LZerD Web Server
Interactions of proteins with other macromolecules have important structural and functional roles in the basic processes of living cells. To understand and elucidate the mechanisms of interactions, it is impor...
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Open AccessA novel hybrid SEIQR model incorporating the effect of quarantine and lockdown regulations for COVID-19
Mitigating the devastating effect of COVID-19 is necessary to control the infectivity and mortality rates. Hence, several strategies such as quarantine of exposed and infected individuals and restricting movem...
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Open AccessExploring the sequence features determining amyloidosis in human antibody light chains
The light chain (AL) amyloidosis is caused by the aggregation of light chain of antibodies into amyloid fibrils. There are plenty of computational resources available for the prediction of short aggregation-pr...
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Open AccessExploring antibody repurposing for COVID-19: beyond presumed roles of therapeutic antibodies
The urgent need for a treatment of COVID-19 has left researchers with limited choice of either develo** an effective vaccine or identifying approved/investigational drugs developed for other medical conditio...
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COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics
The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and ...
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Protein aggregation: in silico algorithms and applications
Protein aggregation is a topic of immense interest to the scientific community due to its role in several neurodegenerative diseases/disorders and industrial importance. Several in silico techniques, tools, an...
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Open AccessA prospective compound screening contest identified broader inhibitors for Sirtuin 1
Potential inhibitors of a target biomolecule, NAD-dependent deacetylase Sirtuin 1, were identified by a contest-based approach, in which participants were asked to propose a prioritized list of 400 compounds f...
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Open AccessInvestigating the energy crisis in Alzheimer disease using transcriptome study
Alzheimer disease (AD) is a devastating neurological disorder, which initiates from hippocampus and proliferates to cortical regions. The neurons of hippocampus require higher energy to preserve the firing pat...
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Open AccessDrug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses
To detect drug candidates for dengue haemorrhagic fever (DHF), we employed a computational drug repositioning method to perform an integrated multiple omics analysis based on transcriptomic, proteomic, and int...
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Book and Conference Proceedings
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Chapter and Conference Paper
Discrimination and Prediction of Protein-Protein Binding Affinity Using Deep Learning Approach
Protein-protein interactions (PPIs) mediate myriad biological functions. Estimating the binding affinity for PPIs help us to understand the underlying molecular recognition mechanism. In this work, we utilized...
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Open AccessAn iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes
We propose a new iterative screening contest method to identify target protein inhibitors. After conducting a compound screening contest in 2014, we report results acquired from a contest held in 2015 in this ...
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Book and Conference Proceedings
Intelligent Computing Methodologies
13th International Conference, ICIC 2017, Liverpool, UK, August 7-10, 2017, Proceedings, Part III
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Chapter and Conference Paper
Influence of Amino Acid Properties for Characterizing Amyloid Peptides in Human Proteome
Amyloidosis denotes the medical disorders associated with deposition of insoluble protein fibrillar aggregates and it is associated with various human diseases. Presence of aggregation prone regions plays an i...
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Protocol
Computational Approaches for Predicting Binding Partners, Interface Residues, and Binding Affinity of Protein–Protein Complexes
Studying protein–protein interactions leads to a better understanding of the underlying principles of several biological pathways. Cost and labor-intensive experimental techniques suggest the need for computat...
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Open AccessAutoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlap** Aggregation Prone and Autoimmunogenic regions
Why do patients suffering from neurodegenerative diseases generate autoantibodies that selectively bind soluble aggregates of amyloidogenic proteins? Presently, molecular basis of interactions between the solu...
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Open AccessHighlights from the 11th ISCB Student Council Symposium 2015
A1 Highlights from the eleventh ISCB Student Council Symposium 2015
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Chapter and Conference Paper
Computational Analysis of Similar Protein-DNA Complexes from Different Organisms to Understand Organism Specific Recognition
Protein-DNA interactions play vital roles in many cellular processes. It is not clear whether the recognition of same protein-DNA complexes in different organisms is similar or different. In this work, we have...
