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Article
COVID-19 outbreak: history, mechanism, transmission, structural studies and therapeutics
The coronavirus outbreak emerged as a severe pandemic, claiming more than 0.8 million lives across the world and raised a major global health concern. We survey the history and mechanism of coronaviruses, and ...
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Article
Open AccessStructural insights into the Middle East respiratory syndrome coronavirus 4a protein and its dsRNA binding mechanism
Middle East respiratory syndrome coronavirus (MERS-CoV) has evolved to navigate through the sophisticated network of a host’s immune system. The immune evasion mechanism including type 1 interferon and protein...
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Article
Open AccessA structural insight into the negative effects of opioids in analgesia by modulating the TLR4 signaling: An in silico approach
Opioids are considered the gold standard therapy for pain. However, TLR-dependent negative effects in analgesia have highlighted the complexities in the pharmacodynamics of opioids. While successive studies ha...
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Article
Toll-like receptors: promising therapeutic targets for inflammatory diseases
The health of living organisms is constantly challenged by bacterial and viral threats. The recognition of pathogenic microorganisms by diverse receptors triggers a variety of host defense mechanisms, leading ...
