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Article
Multidomain Intervention for the Reversal of Cognitive Frailty Using a Personalized Approach (AGELESS Trial): Recruitment and Baseline Characteristics of Participants
Reversal of cognitive frailty through a multidomain intervention is desirable to prevent dementia. AGELESS Trial was conducted to determine the effectiveness of a comprehensive, multidomain intervention on old...
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Article
Open AccessPotentially Modifiable Dementia Risk Factors in Canada: An Analysis of Canadian Longitudinal Study on Aging with a Multi-Country Comparison
It has been suggested that up to 40% of dementia cases worldwide are associated with modifiable risk factors; however, these estimates are not known in Canada. Furthermore, sleep disturbances, an emerging fact...
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Article
Open AccessTemporal Muscle Thickness Predicts Mortality and Disability in Older Adults Diagnosed with Mild Dementia
Sarcopenia contributes to increased hospitalizations, cognitive impairment, falls, and all-cause mortality. Current diagnostic methods, like body Magnetic Resonance Imaging and dual-energy X-ray absorptiometry...
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Article
Open AccessEvaluation of Clinical Meaningfulness of Fortasyn Connect in Terms of “Time Saved”
Assessment of meaningfulness in randomized clinical trials (RCTs) in Alzheimer’s disease (AD) is challenging, particularly in early disease. Converting clinical outcomes to disease progression time allows asse...
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Article
Open AccessCombined Evidence for a Long-Term, Clinical Slowing Effect of Multinutrient Intervention in Prodromal Alzheimer’s Disease: Post-Hoc Analysis of 3-Year Data from the LipiDiDiet Trial
The LipiDiDiet randomized clinical trial is evaluating the long term effects of a multinutrient intervention (Fortasyn Connect) compared with control in participants with prodromal AD. In this post-hoc analysi...
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Article
Open AccessErratum to: Alzheimer’s Disease Composite Score: a Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer’s Disease
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Article
Dementia Prevention: A Global Challenge in Urgent Need of Solutions
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Article
Open AccessMechanisms Underlying Non-Pharmacological Dementia Prevention Strategies: A Translational Perspective
Since develo** an effective treatment for Alzheimer’s disease (AD) has been encountered as a challenging task, attempts to prevent cognitive decline by lifestyle modifications have become increasingly appeal...
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Article
Open AccessBlood Derived Amyloid Biomarkers for Alzheimer’s Disease Prevention
Reliable, widely accessible and affordable biomarkers for predicting Alzheimer’s disease (AD) brain pathology status are a necessity to aid development of prevention strategies in cognitively healthy at-risk o...
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Article
Open AccessDigital Screening for Cognitive Impairment — A Proof of Concept Study
Due to an ageing demographic and rapid increase of cognitive impairment and dementia, combined with potential disease-modifying drugs and other interventions in the pipeline, there is a need for the developmen...
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Article
Open AccessCorrection to: Bisphosphonates and mortality: confounding in observational studies
A Correction to this paper has been published: https://doi.org/10.1007/s00198-021-05884-9
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Article
Open AccessThe European Prevention of Alzheimer’s Dementia (EPAD) Longitudinal Cohort Study: Baseline Data Release V500.0
The European Prevention of Alzheimer’s Dementia (EPAD) Programme is a pan-European project whose objective is to deliver a platform, adaptive, Phase 2 proof of concept (PoC) trial for the secondary prevention ...
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Article
Open AccessAlzheimer’s Disease Composite Score: a Post-Hoc Analysis Using Data from the LipiDiDiet Trial in Prodromal Alzheimer’s Disease
As research evolves in prodromal AD, the need to validate sufficiently sensitive outcome measures, e.g. the Alzheimer’s Disease Composite Score (ADCOMS) is clear. In the LipiDiDiet randomized trial in prodroma...
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Article
Open AccessBisphosphonates and mortality: confounding in observational studies?
Numerous observational studies suggest that bisphosphonates reduce mortality. This study showed that bisphosphonate use is associated with lower mortality within days of treatment, although the association was...
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Article
Association of long-term dietary fat intake, exercise, and weight with later cognitive function in the Finnish Diabetes Prevention Study
To investigate associations of long-term nutrient intake, physical activity and obesity with later cognitive function among the participants in the Finnish Diabetes Prevention Study, in which a lifestyle inter...
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Article
Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses
Accumulating evidence suggests that serum lipids are associated with cognitive decline and dementias. However, majority of the existing information concerns only serum total cholesterol (TC) and data at the le...
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Article
Open AccessMetabolome in progression to Alzheimer's disease
Mild cognitive impairment (MCI) is considered as a transition phase between normal aging and Alzheimer's disease (AD). MCI confers an increased risk of develo** AD, although the state is heterogeneous with s...
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Article
Alzheimer’s disease — The ways of prevention
Several vascular and lifestyle related factors have been suggested to influence the development of dementia and Alzheimer’s disease (AD), creating new prevention opportunities. This paper discusses current epi...
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Article
Decreased brain creatine levels in elderly apolipoprotein E ε4 carriers
Apolipoprotein E (ApoE) genotype has been shown to influence results in neuroimaging studies using a number of various imaging modalities. No in vivo data exists on whether or not there are ApoE-related chang...
