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Article
Open AccessGenetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric dis...
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Article
Open AccessErratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Correction to: Molecular Psychiatry (2017) 22: 1502-1508; advance online publication, 12 July 2017; doi: 10.1038/mp.2016.97 In the first paragraph of the Results section and Figure 1, the authors incorrectly r...
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Article
Open AccessErratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Correction to: Molecular Psychiatry advance online publication, 12 July 2016; doi:10.1038/mp.2016.97 The ninth author’s name was presented incorrectly. It should have been listed as LF Jarskog.
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Article
Open AccessGenome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however, its use is limited by its potential to induce agranulocytosis. The causes of this, and of its precursor neutropeni...
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Article
Open AccessGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipola...
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Article
Open AccessGenetic effects influencing risk for major depressive disorder in China and Europe
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...
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Article
Open AccessSchizophrenia copy number variants and associative learning
Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variant...
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Article
Open AccessPsychiatric gene discoveries shape evidence on ADHD’s biology
A strong motivation for undertaking psychiatric gene discovery studies is to provide novel insights into unknown biology. Although attention-deficit hyperactivity disorder (ADHD) is highly heritable, and large...
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Article
Erratum: Common alleles contribute to schizophrenia in CNV carriers
Correction to: Molecular Psychiatry (2015); advance online publication 22 September 2015; doi:10.1038/mp.2015.143 The first author in Reference 33 was listed incorrectly in the reference list and in the last p...
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Article
Open AccessCommon alleles contribute to schizophrenia in CNV carriers
The genetic architecture of schizophrenia is complex, involving risk alleles ranging from common alleles of weak effect to rare alleles of large effect, the best exemplar of the latter being large copy number ...
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Article
Open AccessCopy number variation in bipolar disorder
Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample fr...
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Article
Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 indi...
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Article
Open AccessAnalysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
Genetic associations involving both rare and common alleles have been reported for schizophrenia but there have been no systematic scans for rare recessive genotypes using fully phased trio data. Here, we use ...
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Article
Evaluating historical candidate genes for schizophrenia
Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for sch...
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Article
Schizophrenia genetics: emerging themes for a complex disorder
After two decades of frustration, genetic studies of schizophrenia have entered an era of spectacular success. Advances in genoty** technologies and high throughput sequencing, increasing analytic rigour and...
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Article
Copy number variation in schizophrenia in Sweden
Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy number variations (CNVs) in SCZ ...
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Article
Open AccessEvidence that duplications of 22q11.2 protect against schizophrenia
A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental disorders, but large, rare, protective CNVs have not been reported for such phenotypes. Here we show in a CNV analysis...
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Article
Common variant at 16p11.2 conferring risk of psychosis
Epidemiological and genetic data support the notion that schizophrenia and bipolar disorder share genetic risk factors. In our previous genome-wide association study, meta-analysis and follow-up (totaling as m...
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Article
Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case–control sample
We have conducted a genoty** study using a custom Illumina Infinium HD genoty** array, the ImmunoChip, in a new UK sample of 1218 bipolar disorder (BD) cases and 2913 controls that have not been used in an...
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Article
Erratum: Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC
Correction to: Molecular Psychiatry advance online publication, 22 May 2012; doi: 10.1038/mp.2012.67 Following the online publication of this article, the authors noted an error in Dr O’Neill's name. The compl...
