16 Result(s)

Article

Early, risk-adapted treatment with fludarabine in Binet stage A chronic lymphocytic leukemia patients: results of the CLL1 trial of the German CLL study group

M A Hoechstetter, R Busch, B Eichhorst, A Bühler, D Winkler, M J Eckart… in Leukemia (2017)

Article

Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH)

Primary mediastinal B-cell lymphoma (PMBL) is an aggressive extranodal B-cell non-Hodgkin's lymphoma with specific clinical, histopathological and genomic features. To characterize further the genotype of PMBL...

S Wessendorf, T F E Barth, A Viardot, A Mueller, H A Kestler, H Kohlhammer… in Leukemia (2007)

Article

High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis

P Liebisch, C Wendl, A Wellmann, A Kröber, G Schilling, H Goldschmidt… in Leukemia (2003)

Article

DNA microarray analysis in malignant lymphomas

Recently, DNA microarray technology has opened new avenues for the understanding of lymphomas. By hybridization of cDNA to arrays containing >10,000 different DNA fragments, this approach allows the simultaneo...

C. Schwaenen, S. Wessendorf, H. A. Kestler, H. Döhner, P. Lichter… in Annals of Hematology (2003)

Article

Klassische und molekulare Zytogenetik in der Hämatologie und Onkologie

K. Döhner, S. Stilgenbauer, S. Fröhling, M. Bentz, H. Döhner in Der Onkologe (2001)

Article

Detection of secondary genetic aberrations in follicle center cell derived lymphomas: assessment of the reliability of comparative genomic hybridization and standard chromosome analysis

Secondary chromosomal aberrations in follicle center cell derived lymphomas (FCDL) usually involve gains and losses of genetic material and may be an important prognostic value. In the present study, we aimed ...

A Viardot, JI Martin-Subero, R Siebert, S Harder, S Gesk, M Bentz… in Leukemia (2001)

Article

BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma

The BCL10 gene has recently been cloned from the 1p22 breakpoint of the translocation t(1;14)(p22;q32) observed in mucosa-associated lymphoid tissue (MALT) lymphoma. BCL10 was shown to be a proapoptotic-signaling...

L Bullinger, E Leupolt, C Schaffner, D Mertens, M Bentz, P Lichter, H Döhner… in Leukemia (2000)

Article

Incidence and clinical significance of 6q deletions in B cell chronic lymphocytic leukemia

Deletions affecting the long arm of chromosome 6 (6q) are among the most commonly observed chromosomal aberrations in lymphoid malignancies and have been identified as adverse prognostic factor in subsets of t...

S Stilgenbauer, L Bullinger, A Benner, K Wildenberger, M Bentz, K Döhner, AD Ho… in Leukemia (1999)

Article

Molecular cytogenetic analysis of B-cell chronic lymphocytic leukemia

 The genetic alterations underlying the pathogenesis of B-cell chronic lymphocytic leukemia (B-CLL) are difficult to assess. Cytogenetic studies are hindered by the low in vitro mitotic activity of the tumor c...

S. Stilgenbauer, K. Döhner, M. Bentz, P. Lichter, H. Döhner in Annals of Hematology (1998)

Chapter and Conference Paper

Molecular Cytogenetic Analysis of Low-Grade B-Cell Neoplasias: a Comparative Genomic Hybridization Study

Malignant tumors are characterized by deregulation of cell proliferation and differentiation, often induced by genomic alterations within the tumor cells (see Fischer et al., this volume). In acute leukemias, ...

C. A. Werner, H. Döhner, T. F. E. Barth… in Advances in Hematopoietic Stem Cell Transp… (1998)

Chapter and Conference Paper

Fluorescence In Situ Hybridization for the Diagnosis and Follow-up of BCR-ABL Positive ALL

The BCR-ABL fusion, which is the molecular counterpart of the t(9;22), is the most common genetic abnormality in adult acute lymphoblastic leukemia (ALL) [1]. Due to its important diagnostic and prognostic sig...

G. P. Cabot, M. Bentz, K. Fischer, A. Ganser, M. Moos, C. Scholl… in Acute Leukemias V (1996)

Chapter and Conference Paper

Designing Probe Sets for the Detection of Chromosome Abnormalities in Acute Myeloid Leukemia Using Fluorescence In Situ Hybridization

In recent years, the karyotype as a prognostic factor in acute myeloid leukemia (AML) has gained considerable interest. Clonal chromosome aberrations are identified in 50–60% of patients with AML (for review s...

K. Fischer, C. Scholl, G. Cabot, M. Moos, R. Schlenk, P. Theobald… in Acute Leukemias V (1996)

Chapter and Conference Paper

Detection of Chromosomal Abnormalities on Previously Stained Peripheral Blood and Bone Marrow Smears

Many hematological malignancies are associated with chromosomal aberrations that, in part, have important clinical significance. The detection of these abnormalities depends on the careful analysis of adequate...

M. Bentz, H. Döhner, M. Schröder, S. Pohl, P. Lichter in Acute Leukemias IV (1994)