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Article
Open AccessLaser-accelerated electron beams at 1 GeV using optically-induced shock injection
In recent years, significant progress has been made in laser wakefield acceleration (LWFA), both regarding the increase in electron energy, charge and stability as well as the reduction of bandwidth of electro...
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Article
Investigating the temporal course, relevance and risk factors of fatigue over 5 years: a prospective study among patients receiving allogeneic HSCT
Although allogeneic hematopoietic stem cell transplantation (HSCT) features severe physical and psychological strain, no previous study has prospectively investigated fatigue beyond 3 years after transplantati...
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Article
Open AccessImproved nutrition in adolescents and young adults after childhood cancer - INAYA study
Multimodality treatment improves the chance of survival but increases the risk for long-term side effects in young cancer survivors, so-called” Adolescents and Young Adults“(AYAs). Compared to the general popu...
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Article
Spättoxizität und Survivorship bei Keimzelltumoren
Keimzelltumoren zählen neben dem M. Hodgkin zu den malignen Erkrankungen mit den aktuell höchsten Heilungsraten, auch noch in weit fortgeschrittenen oder metastasierten Erkrankungsstadien. Dies ist multimodale...
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Article
Toxicity-reduced, myeloablative allograft followed by lenalidomide maintenance as salvage therapy for refractory/relapsed myeloma patients
Relapse after dose-reduced allograft in advanced myeloma patients remains high. To reduce the risk of relapse, we investigated a myeloablative toxicity-reduced allograft (aSCT) consisting of i.v. BU and CY fol...
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Article
Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44+) and T (HLA-DR+) cells
We investigated efficacy and toxicity of lenalidomide in 24 heavily pretreated myeloma patients with a median age of 59 years (range: 37–70) and relapse after allo-SCT. Lenalidomide was given at a dose of 15 mg (
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Article
Phase II trial of vinorelbine and trastuzumab in patients with HER2-positive metastatic breast cancer. A prospective, open label, non-controlled, multicenter phase II trial (to investigate efficacy and safety of this combination chemotherapy)
The purpose of this study was to evaluate the efficacy (progression free survival (PFS) and response rate) and safety of vinorelbine and trastuzumab combination chemotherapy in patients with HER2-overexpressin...
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Article
Erratum: Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma
Correction to: Leukemia (2008) 22, 1250–1255; doi:10.1038/leu.2008.88 Since the publication of the above article, the authors have identified errors in the names of Dr J-A Pérez-Simón and Dr J San Miguel. The ...
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Article
Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma
We analyzed the prognostic impact of the most frequent genetic abnormalities detected by fluorescence in situ hybridization in 101 patients with multiple myeloma, who underwent allogeneic hematopoietic stem cell ...
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Article
High incidence of trisomies 1q, 9q, and 11q in multiple myeloma: results from a comprehensive molecular cytogenetic analysis
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Article
Alexithymie und Somatisierung bei infertilen Männern
In einer vorangegangenen Untersuchung konnten wir nachweisen, dass bei männlicher Infertilität ein höheres Ausmaß an Alexithymie und eine höhere Somatisierung bestehen. In dieser Replikationsstudie werden dies...
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Article
The novel t(11;12;18)(q21;q13;q21) represents a variant translocation of the t(11;18)(q21;q21) associated with MALT-type lymphoma
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Article
Chorioretinopathia centralis serosa und psychische Belastung
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Article
Ungelöste Paarkonflikte bei männlicher Infertilität
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Article
The clinical and genetic correlates of MRI findings in myotonic dystrophy
Amplification of an unstable CTG trinucleotide repeat sequence in a protein kinase gene on chromosome 19 has recently been recognised as the molecular basis of myotonic dystrophy (DM), a multisystem disorder ...
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Chapter
Auslesekriterien für die Auffindung von Körnerlegu-Minosenidiotypen mit N2-Fixierung Nach der Blüte
Die N2-Bindung der Rhizobien erfordert eine reichliche Assimilatversorgung der Wurzelknöllchen. Hieran kann es insbesondere zwischen Blüte und Reife wegen der dann stattfindenden Hülsenfüllung mangeln, was zur He...
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Chapter
C-Bedarf der N2-Fixierung bei Erbsen in Abhängigkeit vom Mikro- und Makrosymbionten und vom Alter der Pflanzen
Der C-Bedarf der N2-Fixierung ist derjenige Anteil der Wachstumsatmung in der Wurzel, der die N2-Fixierung treibt. Experimentelle Bestimmungen dieses Wertes an Erbsenpflanzen zeigen, daß es vor der Blüte starke U...
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Chapter
Der Einfluß von Wachstumssubstrat und Mikrobenbesatz der Wurzel auf die Ausscheidung und Umsetzung organischer Verbindungen in der Rhizosphäre von Maispflanzen
Bei Maispflanzen wurden in Gefäßen mit getrennt begasbarem Wurzel- und Sproßraum (Gefäßgröße: h = 20 cm, Ø = 8 cm) über 5 Tage 14C-Bilanzen erstellt. Die Anzucht erfolgte einerseits in Quarzsand. Zum anderen gab ...
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Article
The influence of N2-fixation on the carbon balance of leguminous plants
Biological dinitrogen fixation by legume-rhizobia symbiosis is very important both from the economic and from the ecological point of view. Theoretically, the reduction of the N2-molecule to ammonia requires at l...
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Article
Nonlinear laser ablation from solid rare-gas films
Optical breakdown on Ar films is studied in an intensity range from 106 to 2 × 109 W/cm2 for wavelengths of 228, 281 and 282.8 nm. The amount of ablated H2O, N2, O2 and Ar increases quadratically with laser inten...
