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Article
Such Various Stem Cells
Perhaps there is no more intriguing topic in modern biology than stem cells. The growing interest in stem cells is dictated by the ability of stem cells to both self-renew and differentiate, at least into seve...
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Article
Development of Hematopoietic Stem Cells in the Early Mammalian Embryo
Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the f...
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Article
“Necessity Is the Mother of Invention” or Inexpensive, Reliable, and Reproducible Protocol for Generating Organoids
Organoids are three-dimensional (3D) cell cultures that replicate some of the key features of morphology, spatial architecture, and functions of a particular organ. Organoids can be generated from both adult a...
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Article
The Diverse Roles of Spliceosomal Proteins in the Regulation of Cell Processes
The spliceosome is necessary for the removal of intron sequences in transcribed pre-mRNA in eukaryotic cells. More than 200 proteins are involved in the process of pre-mRNA splicing; they coordinate the altern...
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Article
Pluripotent Stem Cells for Modelling and Cell Therapy of Parkinson’s Disease
Studying pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), requires adequate disease models. The available patient’s material is limited to biological fluids and post mortem brain sa...
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Article
Molecular barriers to processes of genetic reprogramming and cell transformation
Genetic reprogramming by ectopic expression of transcription factor genes induces the pluripotent state in somatic cells. This technology provides an opportunity to establish pluripotent stem cells for each pe...