11 Result(s)

Article

The Role of Mutant RNA in the Pathogenesis of Huntington’s Disease and Other Polyglutamine Diseases

Polyglutamine diseases are rare, inherited neurodegenerative pathologies that arise as a result of expansion of trinucleotide CAG repeats in the coding segment of certain genes. This expansion leads to the app...

A. N. Bogomazova, A. V. Eremeev, G. E. Pozmogova, M. A. Lagarkova in Molecular Biology (2019)

Article

At Home among Strangers: Is It Possible to Create Hypoimmunogenic Pluripotent Stem Cell Lines?

Human pluripotent stem cells, which include embryonic stem cells and induced pluripotent cells (iPSCs), are capable of unlimited division and differentiation into all cells of the body. These cells are conside...

M. E. Bogomiakova, A. V. Eremeev, M. A. Lagarkova in Molecular Biology (2019)

Article

Such Various Stem Cells

Perhaps there is no more intriguing topic in modern biology than stem cells. The growing interest in stem cells is dictated by the ability of stem cells to both self-renew and differentiate, at least into seve...

M. A. Lagarkova in Biochemistry (Moscow) (2019)

Article

Development of Hematopoietic Stem Cells in the Early Mammalian Embryo

Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the f...

S. A. Rybtsov, M. A. Lagarkova in Biochemistry (Moscow) (2019)

Article

“Necessity Is the Mother of Invention” or Inexpensive, Reliable, and Reproducible Protocol for Generating Organoids

Organoids are three-dimensional (3D) cell cultures that replicate some of the key features of morphology, spatial architecture, and functions of a particular organ. Organoids can be generated from both adult a...

A. V. Eremeev, E. A. Volovikov, L. D. Shuvalova, A. V. Davidenko… in Biochemistry (Moscow) (2019)

Article

The Diverse Roles of Spliceosomal Proteins in the Regulation of Cell Processes

The spliceosome is necessary for the removal of intron sequences in transcribed pre-mRNA in eukaryotic cells. More than 200 proteins are involved in the process of pre-mRNA splicing; they coordinate the altern...

K. S. Anufrieva, V. O. Shender, G. P. Arapidi… in Russian Journal of Bioorganic Chemistry (2019)

Article

Pluripotent Stem Cells for Modelling and Cell Therapy of Parkinson’s Disease

Studying pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), requires adequate disease models. The available patient’s material is limited to biological fluids and post mortem brain sa...

O. S. Lebedeva, M. A. Lagarkova in Biochemistry (Moscow) (2018)

Article

Molecular barriers to processes of genetic reprogramming and cell transformation

Genetic reprogramming by ectopic expression of transcription factor genes induces the pluripotent state in somatic cells. This technology provides an opportunity to establish pluripotent stem cells for each pe...

I. V. Chestkov, E. A. Khomyakova, E. A. Vasilieva, M. A. Lagarkova… in Biochemistry (Moscow) (2014)

Article

Serological Analysis of the Repertoire of Human Cancer Antigens and Autoantigens

The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to sea...

E. P. Koroleva, M. A. Lagarkova, S. V. Khlgatian, Yu. V. Shebzukhov… in Molecular Biology (2004)

Article

Analysis of Chromatin Structural Transitions by Means of Intercalator Dyes

W. A. Krajewski, M. A. Lagarkova, N. P. Sharova… in Doklady Biochemistry and Biophysics (2001)

Article

Effect of Histone Terminal Domains on Chromatin Structural Transitions

V. A. Krajewski, M. A. Lagarkova, N. P. Sharova… in Doklady Biochemistry and Biophysics (2001)