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Article
HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis
Most of the published works so far have aimed at finding genes associated with multiple sclerosis (MS) susceptibility. Very few studies have attempted to correlate disease features with DNA variants. In a well...
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Article
IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
Multiple sclerosis (MS) is the most common chronic inflammatory neurologic disorder diagnosed in young adults and, due to its chronic course, is responsible for a substantial economic burden. MS is considered ...
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Article
Response
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Article
Chromosome 17q22–q24 and multiple sclerosis genetic susceptibility
Recently, genome-wide searches for multiple sclerosis (MS) susceptibility genes have suggested that the chromosome 17q22–q24 region might contain susceptibility genes in two sets of families of different ethni...
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Chapter and Conference Paper
Family Studies of Affective Disorders with 11p15.5 DNA Markers
Family, twin, and adoption studies suggest the involvement of genetic factors in manic-depressive illness (MDI) but the mode of inheritance remains elusive. The remarkable success with which the classical loga...
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Chapter and Conference Paper
Genetic Epidemiology of Retinoblastoma
The retinoblastoma story provides a very good example of a case where mechanisms assessed by genetic epidemiology were confirmed several years later by molecular genetics. There are still some questions raised...
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Article
Gene for chronic proximal spinal muscular atrophies maps to chromosome 5q
PROXIMAL spinal muscular atrophies represent the second most common fatal, autosomal recessive disorder after cystic fibrosis1. The childhood form is classically subdivided into three groups: acute Werdnig-Hoffm...