Abstract
Family, twin, and adoption studies suggest the involvement of genetic factors in manic-depressive illness (MDI) but the mode of inheritance remains elusive. The remarkable success with which the classical logarithm of odds (lod) score method has contributed to the localization of loci for numerous diseases has led many authors to apply this strategy to complex illnesses such as affective disorders. Most pertinent was the study conducted by Egeland et al. in 1987, which was based on an extended pedigree in order to minimize a possible genetic heterogeneity. These investigators reported a linkage between MDI and insulin (INS) and c-Harvey-ras-1 oncogene (HRAS) markers located within 11p15. But a recent reinvestigation of the Amish pedigree and the study of a set of non-Amish pedigrees call into question this initial finding (Kelsoe et al. 1989).
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References
Black IB, Adler JE, Dreyfus CF, Jonakait GM, Katz DM, LaGamma EF, Markey KM (1984) Neurotransmitter plasticity at the molecular level. Science 225: 1266–1270
Black IB, Chikaraishi DM, Lewis EJ (1985) Trans-synaptic increase in RNA coding for tyrosine hydroxylase in rat sympathic ganglion. Brain Res 339: 151–153
Black IB, Adler JE, Dreyfus CF, Freidman WF, La Gamma EF, Roach AH (1987) Biochemistry of information storage in the nervous system. Science 236: 1263–1268
Cambell DG. Hardie DG, Vulliet PR (1986) Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase. J Biol Chem 261: 10489–10492
Comb M, Hyman SE, Goodman HM (1987) Mechanisms of transsynaptic regulation of gene expression. TINS 10: 473–478
EgelandJ, Gerhard D, Pauls D, Sussex J, Kidd K, Allen C, Hostetter A, Housman D (1987) Bipolar affective disorders linked to DNA markers onchromosome 11. Nature 325: 783–787
Faucon Biguet N, Buda M, Lamouroux A, Mallet J (1986) Time course of the changes of TH mRNA in rat brain and adrenal medulla after a single injection of reserpine. EMBO J 5: 287–291
Gill M, Castle D, Hunt N, Clements A, Sham P, Murray RM (1992) Tyrosine hydroxylase polymorphisms and bipolar affective disorder. J Psychiatr Res (in press)
Grima B, Lamouroux A, Boni C, Julien JF, Javoy-Agid F, Mallet J (1987) A single human gene encodes multiple tyrosine hydroxylases predicted to differ in their functional characteristics. Nature 326: 707–711
Haycock JW (1990) Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. J Biol Chem 265: 1–10
Horellou P, Le Bourdellès B, Clot-Humbert J. Guibert B, Leviel V, Mallet J (1988) Multiple tyrosine hydroxylase enzymes, generated through alternative splicing, have different specific activities in Xenopus oocytes. J Neurochem 51: 652–655
Kaneda N, Kobayashi K, Ichinose H, Kishi F, Nakazawa A, Kurosawa Y, Fujita K, Nagatsu T (1987) Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative mRNA splicing produces four kinds of mRNA from a single gene. Biochem Biophys Res Commun 146: 971–975
Kelsoe J, Ginns E, Egeland J, Gerhardt D, Goldstein A, Bale S, Pauls D, Long R, Kidd K, Conte G, Housman D, Paul S (1989) Re-evaluation of the linkage relationship between chromosome 11 p loci and the gene for bipolar affective disorder in the Old Order Amish. Nature 342: 238–243
Kobayashi K, Kiuchi K, Ishii A, Kaneda N, Kurosawa Y, Fujita K, Nagatsu T (1988) Expression of four types of human tyrosine hydroxylase in COS cells. FEBS Lett 238: 431–434
Körner J, Fritze J, Prop** P (1990) RFLP alleles at the tyrosine hydroxylase locus: no association found to affective disorders. Psychiatry Res 32: 275–280
Le Bourdellès B, Boularand S, Boni C, Horellou P, Dumas S, Grima B, Mallet J (1988). Analysis of the 5’ region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. J Neurochem 50: 988–991
Le Bourdellès B, Horellou P, LeCaer J, Denèfle P, Latta M, Haavik J, Guibert B, Mayaux JF, Mallet J (1991) Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing. J Bio Chem 266: 17124–17130
Leboyer M, Malafosse A, Boularand S, Campion D, Gheysen F, Samolyk D, Henrikkson B, Denise E, Des Lauriers A, Lépine JP, Zarifian E, Clerget-Darpoux F, Mallet J (1990) Tyrosine hydroxylase polymorphisms associated with manic-depressive illness. Lancet 335: 1219
Weeks DE, Lange K (1988) The affected pedigree member method of linkage analysis. Am J Hum Genet 42: 315–326
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© 1992 Springer-Verlag Berlin Heidelberg
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Mallet, J. et al. (1992). Family Studies of Affective Disorders with 11p15.5 DNA Markers. In: Mendlewicz, J., Hippius, H., Bondy, B., Ackenheil, M., Sandler, M. (eds) Genetic Research in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46762-2_14
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DOI: https://doi.org/10.1007/978-3-642-46762-2_14
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