62 Result(s)

Article

Development and evaluation of MALDI-TOF MS-based seroty** for Streptococcus pneumoniae

Surveillance of Streptococcus pneumoniae serotypes is important for the successful implementation of vaccination strategies to prevent the spread of invasive pneumococcal diseases. The standard method of serotypi...

S. Nakano, Y. Matsumura, Y. Ito, T. Fujisawa… in European Journal of Clinical Microbiology … (2015)

Article

Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery

Precise fluorescence-guided surgery (FGS) for pancreatic cancer has the potential to greatly improve the outcome in this recalcitrant disease. To achieve this goal, we have used genetic reporters to color code...

S Yano, Y Hiroshima, A Maawy, H Kishimoto, A Suetsugu, S Miwa… in Cancer Gene Therapy (2015)

Article

Seasonal trend and clinical presentation of Bacillus cereus bloodstream infection: association with summer and indwelling catheter

Bacillus cereus, an opportunistic pathogen, can cause fatal infection. However, B. cereus bloodstream infections (BSIs) have not been well characterised. From 2008 to 2013, B. cereus isol...

K. Kato, Y. Matsumura, M. Yamamoto, M. Nagao… in European Journal of Clinical Microbiology … (2014)

Article

Long-term correction of biochemical and neurological abnormalities in MLD mice model by neonatal systemic injection of an AAV serotype 9 vector

As both the immune system and the blood–brain barrier (BBB) are likely to be developmentally immature in the perinatal period, neonatal gene transfer may be useful for the treatment of lysosomal storage diseas...

N Miyake, K Miyake, N Asakawa, M Yamamoto, T Shimada in Gene Therapy (2014)

Article

Effect of increased viral replication and infectivity enhancement on radioiodide uptake and oncolytic activity of adenovirus vectors expressing the sodium iodide symporter

Our laboratory has investigated replicating adenovirus-human sodium iodide symporter (Ad-hNIS) vectors in a combinatorial oncolytic approach known as radiovirotherapy. However, hNIS-mediated iodide sequestrati...

M J Oneal, M A Trujillo, J Davydova, S McDonough, M Yamamoto… in Cancer Gene Therapy (2013)

Article

Cefotaxime for the detection of extended-spectrum β-lactamase or plasmid-mediated AmpC β-lactamase and clinical characteristics of cefotaxime-non-susceptible Escherichia coli and Klebsiella pneumoniae bacteraemia

We investigated the performance of cefotaxime for the detection of extended-spectrum β-lactamase (ESBL) or plasmid-mediated AmpC β-lactamase (pAmpC) and the clinical characteristics of cefotaxime-non-susceptible

Y. Matsumura, M. Yamamoto, A. Matsushima… in European Journal of Clinical Microbiology … (2012)

Article

Regional spread and control of vancomycin-resistant Enterococcus faecium and Enterococcus faecalis in Kyoto, Japan

The purpose of this investigation was to control the post-outbreak prevalence of vancomycin-resistant enterococci (VRE) in the affected Kyoto region. The study period was from 2005 to 2010. Faecal samples were...

A. Matsushima, S. Takakura, M. Yamamoto… in European Journal of Clinical Microbiology … (2012)

Chapter

M Cell-Targeted Mucosal Vaccine Strategies

Immune responses in the aerodigestive tract are characterized by production and transport of specific IgA antibodies across the epithelium to act as a first line of defense against pathogens in the external en...

M. Yamamoto, D. W. Pascual, H. Kiyono in Mucosal Vaccines (2012)

Article

Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case–control study

Genetic risk factors for ticlopidine-induced hepatotoxicity were determined in 22 Japanese patients with ticlopidine-induced hepatotoxicity and 85 Japanese patients who tolerated ticlopidine therapy without ex...

K Hirata, H Takagi, M Yamamoto, T Matsumoto, T Nishiya… in The Pharmacogenomics Journal (2008)

Article

Poster abstracts

J. Ferrie, M. Shipley, F. Cappuccio, E. Brunner, M. Miller… in Sleep and Biological Rhythms (2007)

Article

Interferon-γ inhibits collagen phagocytosis in human fibroblasts by inducing subcortical actin assembly and reducing ability of β1 integrin to bind to collagen

We investigated the possible roles of interferon-γ (IFN-γ) in modulation of extracellular and intracellular routes of collagen digestion by human fibroblasts.

T. Takaki, M. Kobayashi, K. Okubo, N. Takahashi, Y. Okamatsu… in Inflammation Research (2006)

Article

Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents

Whereas virotherapy has emerged as a novel and promising approach for neoplastic diseases, appropriate model systems have hampered preclinical evaluation of candidate conditionally replicative adenovirus agent...

M A Stoff-Khalili, A A Rivera, L P Le, A Stoff, M Everts… in Cancer Gene Therapy (2006)

Article

The carcinoma-specific epithelial glycoprotein-2 promoter controls efficient and selective gene expression in an adenoviral context

Adenoviral vectors are widely used in cancer gene therapy. After systemic administration however, the majority of the virus homes to the liver and the expressed transgene may cause hepatotoxicity. To restrict ...

W M Gommans, S J van Eert, P M J McLaughlin, M C Harmsen, M Yamamoto… in Cancer Gene Therapy (2006)

Article

Suppressor of cytokine signaling-1 expression by infectivity-enhanced adenoviral vector inhibits IL-6-dependent proliferation of multiple myeloma cells

Multiple myeloma (MM) accounts for 10% of hematological malignant disorders. Its refractory nature indicates the necessity of develo** novel therapeutic modalities. Since interleukin 6 (IL-6) is one of the m...

M Yamamoto, N Nishimoto, J Davydova, T Kishimoto, D T Curiel in Cancer Gene Therapy (2006)

Article

Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress

Helicobacter pylori infection, as well as NSAIDs induce oxidative stress on gastric mucosa, thereby causing mucosal damage and retarding mucosal repair. Cells can survive against chronic oxidative stress by enhan...

A. Yanaka, S. Zhang, M. Tauchi, H. Suzuki, T. Shibahara, H. Matsui… in InflammoPharmacology (2005)