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127 Result(s)
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Article
Open AccessBlockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells
We have reported that an environmental pollutant, cadmium, promotes cell death in the human renal tubular cells (RTCs) through hyperactivation of a serine/threonine kinase Akt. However, the molecular mechanism...
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Open AccessParticle size distributions inside and around the artificial crater produced by the Hayabusa2 impact experiment on Ryugu
Japanese Hayabusa2 spacecraft has successfully carried out an impact experiment using a small carry-on impactor (SCI) on an asteroid (162173) Ryugu. We examine the size distribution of particles inside and out...
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Surgical resection of primary tumor in the extremities improves survival for metastatic soft-tissue sarcoma patients: a population-based study of the SEER database
The objectives of this study were to clarify whether resection of primary tumor in the extremities for patients with metastatic soft-tissue sarcoma (STS) improves survival, and to clarify patient groups for wh...
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Anomalously porous boulders on (162173) Ryugu as primordial materials from its parent body
Planetesimals—the initial stage of the planetary formation process—are considered to be initially very porous aggregates of dusts1,2, and subsequent thermal and compaction processes reduce their porosity3. The Ha...
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Thermally altered subsurface material of asteroid (162173) Ryugu
Analyses of meteorites and theoretical models indicate that some carbonaceous near-Earth asteroids may have been thermally altered due to radiative heating during close approaches to the Sun1–3. However, the lack...
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Collisional history of Ryugu’s parent body from bright surface boulders
The asteroid (162173) Ryugu and other rubble-pile asteroids are likely re-accumulated fragments of much larger parent bodies that were disrupted by impacts. However, the collisional and orbital pathways from t...
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Article
Sex Change in Protogynous Fish Red-Belted Anthias Pseudanthias rubrizonatus (Serranidae) in Kagoshima Bay, Japan
The Serranidae are well known for protogynous sex change. The red-belted anthias Pseudanthias rubrizonatus inhabits Kagoshima Bay. We aimed to estimate the body size and age of P. rubrizonatus exhibiting sex chan...
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Article
PU.1 acts as tumor suppressor for myeloma cells through direct transcriptional repression of IRF4
We previously reported that PU.1 is downregulated in the majority of myeloma cell lines and primary myeloma cells of certain myeloma patients, and conditional expression of PU.1 in such myeloma cell lines indu...
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Article
HTLV-1 bZIP factor protein targets the Rb/E2F-1 pathway to promote proliferation and apoptosis of primary CD4+ T cells
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus that induces a fatal T-cell malignancy, adult T-cell leukemia (ATL). Among several regulatory/accessory genes in HTLV-1, HTLV-1 bZIP factor (...
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Article
Involvement of double-stranded RNA-dependent protein kinase and antisense viral RNA in the constitutive NFκB activation in adult T-cell leukemia/lymphoma cells
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Article
Open AccessDetrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells
We examined the roles of Notch1 signaling and its cross-talk with other signaling pathways, including p53 and phosphatidylinositol-3-kinase (PI3K)/Akt, in cadmium-induced cellular damage in HK-2 human renal pr...
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Article
HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells
Human T-cell leukemia virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). HTLV-1 bZIP factor (HBZ), the viral gene transcribed from the antisense strand, is consistently expressed in A...
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Article
Open AccessSecreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer’s disease models via the heterotrimeric Humanin receptor
Humanin is a secreted bioactive peptide that is protective in a variety of death models, including cell-based neuronal death models related to Alzheimer’s disease (AD). To mediate the protective effect in AD-r...
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Article
Identification and characterization of intergeneric hybrid of commercial sugarcane (Saccharum spp. hybrid) and Erianthus arundinaceus (Retz.) Jeswiet
To generate drought-tolerant sugarcane, we obtained hybrid lines by the intergeneric hybridization of a Saccharum spp. hybrid with Erianthus arundinaceus. A test using 5S rDNA as a marker identified five intergen...
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Article
Reduced expression of BTBD10, an Akt activator, leads to motor neuron death
BTBD10, an Akt interactor, activates Akt by decreasing the protein phosphatase 2A-mediated dephosphorylation and inactivation of Akt. Overexpression of BTBD10 suppresses motor neuron death that is induced by a...
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Article
Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virall...
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Article
Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
Elevation of intracranial soluble amyloid-β (Aβ) levels has been implicated in the pathogenesis of Alzheimer's disease (AD). Intracellular events in neurons, which lead to memory loss in AD, however, remain el...
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Article
Energy Band States of an Oxygen-doped GeSbTe Phase-change Memory Cell; Mechanism of Low-voltage Operation
Phase-change memory is promising because it has a simple structure and has scalability that originates from its unique operating mechanism. However, the programming current should be reduced in accordance with...
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Article
The Effect of Chemical Etching by HF Solution on the Photocatalytic Activity of Visible Light-responsive TiO2 Thin Films for Solar Water Splitting
The effect of chemical etching by HF solution on the photoelectrochemical performance and photocatalytic activity of visible light-responsive TiO2 (Vis-TiO2) thin films prepared by a radio-frequency magnetron spu...
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Article
Effect of HF treatment on the activity of TiO2 thin films for photocatalytic water splitting
The effects of HF treatment on the activity of TiO2 thin films for the photocatalytic water splitting reaction have been investigated. TiO2 thin films treated with HF solution (HF-TiO2) were found to exhibit a re...