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Article
Cystinuria: absence of lysine permeability in the brush border membrane of intestinal cells
The mechanism of impaired transport of cystine and dibasic amino acids in the jejunum and the kidney of cystinuric patients is poorly understood. Na-dependent L-lysine intestinal transport has been assessed, i...
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Article
Intestinal permeability to macromolecules during viral enteritis in conventional and germ-free suckling mice
Epithelial transport and degradation of horseradish peroxidase (HRP) was studied in conventional and germ-free suckling mice following an experimental infection with rotavirus. Conventional and germ-free mice ...
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Article
15 ANTICEN ABSORPTION IN CHILDREN WITH COW'S MILK PROTEIN INTOLERANCE
Intestinal absorption of exogenous proteins was studied in infants with cow's milk protein intolerance (CMPI) during the initial period of diagnosis, at the age of 3 ± 1 months and one year later just before a...
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Article
51 CHOLERA TOXIN STIMULATES NA+-GLUCOSE COTRANSPORT IN A HUMAN EPITHELIAL SECRETORY CELL LINE
Cholera toxin (CT) stimulates chloride secretion in the crypt cells with preservation of the Na+-glucose cotransport in the vlllus cells. The role of CT on the relationship between Cl secretion and glucose absorp...
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Article
55 PROTEIN ENDOCYTOSIS AND PROCESSING BY VILLUS AND CRYPT CELLS OF THE MOUSE SMALL INTESTINE
The transport of proteins across the epithelial cells of small intestine is increased after rotavirus infection but it remains unaltered in secretory diarrhea. In addition, the cell turnover is increased in ro...
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Article
INCREASED ANTICEN ABSOBPTIN INDUCED BY INFECTION WITH THE ADHERENT ENTEROPATHOCENIC E.COLI STRAIN RDEC-1 IN RABBIT ILEUH AND PEYER'S PATCHES
Intestinal absorption of antigenic (intact) and degraded β-lacto-globulin (β-lg) and horseradish perioxidase (HRP) was studied in rabbits experimentally infected at weaning with the rabbit-specific Escherichia...
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Article
EFFECT OF CLOSTRIDIUM DIFFICILE TOXINS ON THE CAECAL EPITHELIAL BARRIER
The most striking effect of Clostridium difficile infection is its degrading of the intestinal barrier. The aim of this study was to characterize the effect of C. difficile toxins on the epithelial layer inclu...
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Article
EFFECT OF ORAL OR PARENTERAL SENSITIZATION TO COW'S MILK ON MUCOSAL PERMEABILITY IN GUINEA-PIGS
The systemic and local immune responses and intestinal barrier function were examined in orally or parenterally milk-sensitized guinea-pigs. Both types of sensitization led to positive passive cutaneous anaphy...
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Article
Autotransplantation for advanced lymphoma and Hodgkin's disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy
Disease relapse occurs in 50% or more of patients who are autografted for relapsed or refractory lymphoma (NHL) or Hodgkin's disease (HD). The administration of non-cross-resistant therapies during the post-tr...
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Article
Probiotic microorganisms: how they affect intestinal pathophysiology
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Article
Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92
Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic...
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Article
High-dose cyclophosphamide with or without etoposide for mobilization of peripheral blood progenitor cells in patients with multiple myeloma: efficacy and toxicity
The purpose of the study was to examine the yield of CD34+ cells, response rates, and toxicity of high-dose cyclophosphamide with or without etoposide in patients with multiple myeloma. In total, 77 myeloma patie...
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Article
Autologous stem cell transplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin's lymphoma
Relapse remains a major cause of treatment failure after autotransplantation (auto-PBSCT) for Hodgkin's disease (HD). The administration of non-crossresistant therapies during the post-transplant period may de...
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Article
Autologous stem cell transplantation followed by consolidation chemotherapy for patients with multiple myeloma
Although high-dose therapy and autologous stem cell transplant (ASCT) is superior to conventional chemotherapy for treatment of myeloma, most patients relapse and the time to relapse depends upon the initial p...
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Article
Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?
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Article
Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome
We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from children with acute lymphoblastic leukemia (ALL). Patien...
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Article
Erratum: Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
Correction to: Cell Death and Differentiation (2009) 16, 1018–1029; doi:10.1038/cdd.2009.46; published online 24 April 2009 Since the publication of their paper, the authors have noticed that the name of the f...
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Article
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. Recent studies, however, showed that an alternative ...
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Article
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
Analysis of 2668 children with acute lymphoblastic leukemia (ALL) treated in two successive Nordic clinical trials (Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL-92 and ALL-2000) showed tha...
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Article
Erratum: Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
Correction to: Leukemia (2010) 2, 345–354; doi:10.1038/leu.2009.251 Since the publication of this paper, the authors have noticed an error in Table 1. The correct version is shown below. The authors apologize ...
