29 Result(s)

Article

T-cell acute lymphoblastic leukemia in patients 1–45 years treated with the pediatric NOPHO ALL2008 protocol

The NOPHO ALL2008 is a population-based study using an unmodified pediatric protocol in patients 1–45 years of age with acute lymphoblastic leukemia. Patients with T-ALL were given a traditional pediatric sche...

P. Quist-Paulsen, N. Toft, M. Heyman, J. Abrahamsson, L. Griškevičius… in Leukemia (2020)

Article

Results of NOPHO ALL2008 treatment for patients aged 1–45 years with acute lymphoblastic leukemia

Adults with acute lymphoblastic leukemia (ALL) do worse than children. From 7/2008 to 12/2014, Nordic and Baltic centers treated 1509 consecutive patients aged 1–45 years with Philadelphia chromosome-negative ...

N Toft, H Birgens, J Abrahamsson, L Griškevičius, H Hallböök, M Heyman… in Leukemia (2018)

Article

Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol

Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0–17.9 years) diagnosed during July 2008–December 2014 and treated according to the...

B O Wolthers, T L Frandsen, J Abrahamsson, B K Albertsen, L R Helt, M Heyman… in Leukemia (2017)

Article

Early morbidity and mortality in childhood acute lymphoblastic leukemia with very high white blood cell count

G Vaitkeviciene, M Heyman, O G Jonsson, B Lausen, A Harila-Saari, M Stenmarker… in Leukemia (2013)

Article

Impact of IKZF1 deletions and PAX5 amplifications in pediatric B-cell precursor ALL treated according to NOPHO protocols

I Öfverholm, A N Tran, M Heyman, V Zachariadis, M Nordenskjöld, A Nordgren… in Leukemia (2013)

Article

Physicians compliance during maintenance therapy in children with Down syndrome and acute lymphoblastic leukemia

Children with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have an inferior prognosis compared with non-DS ALL patients. We reviewed methotrexate (MTX)/mercaptopurine (6MP) maintenance therapy dat...

C Bohnstedt, M Levinsen, S Rosthøj, B Zeller, M Taskinen, S Hafsteinsdottir… in Leukemia (2013)

Article

The frequency and prognostic impact of dic(9;20)(p13.2;q11.2) in childhood B-cell precursor acute lymphoblastic leukemia: results from the NOPHO ALL-2000 trial

The dic(9;20)(p13.2;q11.2) is reported to be present in ∼2% of childhood B-cell precursor acute lymphoblastic leukemia (BCP ALL). However, it easily escapes detection by G-banding analysis and its true prevale...

V Zachariadis, F Gauffin, E Kuchinskaya, M Heyman, J Schoumans, E Blennow… in Leukemia (2011)

Article

The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse

Drug doses, blood levels of drug metabolites and myelotoxicity during 6-mercaptopurine/methotrexate (MTX) maintenance therapy were registered for 59 adolescents (⩾10 years) and 176 non-adolescents (<10 years) ...

K Schmiegelow, M Heyman, G Gustafsson, B Lausen, F Wesenberg, J Kristinsson… in Leukemia (2010)

Article

Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia

Analysis of 2668 children with acute lymphoblastic leukemia (ALL) treated in two successive Nordic clinical trials (Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL-92 and ALL-2000) showed tha...

K Schmiegelow, E Forestier, M Hellebostad, M Heyman, J Kristinsson, S Söderhäll… in Leukemia (2010)

Article

Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome

We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from children with acute lymphoblastic leukemia (ALL). Patien...

U Norén-Nyström, G Roos, A Bergh, J Botling, G Lönnerholm, A Porwit, M Heyman… in Leukemia (2008)

Article

Tiling-resolution array-CGH reveals the pattern of DNA copy number alterations in acute lymphoblastic leukemia with 21q amplification: the result of telomere dysfunction and breakage/fusion/breakage cycles?

E Kuchinskaya, A Nordgren, M Heyman, J Schoumans, M Corcoran, J Staaf, Å Borg… in Leukemia (2007)

Article

Autologous stem cell transplantation followed by consolidation chemotherapy for patients with multiple myeloma

Although high-dose therapy and autologous stem cell transplant (ASCT) is superior to conventional chemotherapy for treatment of myeloma, most patients relapse and the time to relapse depends upon the initial p...

I Gojo, B Meisenberg, C Guo, A Fassas, A Murthy, R Fenton… in Bone Marrow Transplantation (2006)

Article

Autologous stem cell transplantation followed by consolidation chemotherapy for relapsed or refractory Hodgkin's lymphoma

Relapse remains a major cause of treatment failure after autotransplantation (auto-PBSCT) for Hodgkin's disease (HD). The administration of non-crossresistant therapies during the post-transplant period may de...

A P Rapoport, C Guo, A Badros, R Hakimian, G Akpek… in Bone Marrow Transplantation (2004)

Article

High-dose cyclophosphamide with or without etoposide for mobilization of peripheral blood progenitor cells in patients with multiple myeloma: efficacy and toxicity

The purpose of the study was to examine the yield of CD34⁺ cells, response rates, and toxicity of high-dose cyclophosphamide with or without etoposide in patients with multiple myeloma. In total, 77 myeloma patie...

I Gojo, C Guo, C Sarkodee-Adoo, B Meisenberg, A Fassas… in Bone Marrow Transplantation (2004)

Article

Deletion of the Ink4-locus (the p16ink4a, p14ARF and p15ink4b genes) predicts relapse in children with ALL treated according to the Nordic protocols NOPHO-86 and NOPHO-92

Inactivation of the Ink4 gene locus locus on 9p comprising the tumour suppressor gene p16ink4a and its neighbours p14ARF and p15ink4b is common in childhood acute lymphoblastic leukaemia (ALL), but the prognostic...

TM Calero Moreno, G Gustafsson, S Garwicz, D Grandér, GK Jonmundsson, B-M Frost… in Leukemia (2002)

Article

Probiotic microorganisms: how they affect intestinal pathophysiology

M. Heyman, S. Ménard in Cellular and Molecular Life Sciences CMLS (2002)