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Protocol
A Practical Approach to Using the Genomic Standards Consortium MIxS Reporting Standard for Comparative Genomics and Metagenomics
Comparative analysis of (meta)genomes necessitates aggregation, integration, and synthesis of well-annotated data using standards. The Genomic Standards Consortium (GSC) collaborates with the research communit...
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Article
Open AccessModeling the enigma of complex disease etiology
Complex diseases often present as a diagnosis riddle, further complicated by the combination of multiple phenotypes and diseases as features of other diseases. With the aim of enhancing the determination of ke...
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Article
Open AccessA comprehensive update on CIDO: the community-based coronavirus infectious disease ontology
The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of develo** effective and saf...
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Article
A community approach to the cancer-variant-interpretation bottleneck
As guidelines, therapies and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public-domain, crowd-sourced and adaptable knowledgeba...
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Article
Open AccessCOVID-19 pandemic reveals the peril of ignoring metadata standards
Efficient response to the pandemic through the mobilization of the larger scientific community is challenged by the limited reusability of the available primary genomic data. Here, the Genomic Standards Consor...
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Article
Open AccessA harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer
Precision oncology relies on accurate discovery and interpretation of genomic variants, enabling individualized diagnosis, prognosis and therapy selection. We found that six prominent somatic cancer variant kn...
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Article
Open AccessFoodOn: a harmonized food ontology to increase global food traceability, quality control and data integration
The construction of high capacity data sharing networks to support increasing government and commercial data exchange has highlighted a key roadblock: the content of existing Internet-connected information rem...
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Article
Open AccessMolecular, phenotypic, and sample-associated data to describe pluripotent stem cell lines and derivatives
The use of induced pluripotent stem cells (iPSC) derived from independent patients and sources holds considerable promise to improve the understanding of development and disease. However, optimized use of iPSC...
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Article
Open AccessThe Disease Ontology: fostering interoperability between biological and clinical human disease-related data
The Disease Ontology (DO) enables cross-domain data integration through a common standard of human disease terms and their etiological descriptions. Standardized disease descriptors that are integrated across ...
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Article
Open AccessReport of the 13th Genomic Standards Consortium Meeting, Shenzhen, China, March 4–7, 2012
This report details the outcome of the 13th Meeting of the Genomic Standards Consortium. The three-day conference was held at the Kingkey Palace Hotel, Shenzhen, China, on March 5–7, 2012, and was hosted by the B...
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Article
Open AccessMetagenomics: A foundling finds its feet
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Chapter and Conference Paper
Gemina: A Web-Based Epidemiology and Genomic Metadata System Designed to Identify Infectious Agents
The Gemina system (http://gemina.tigr.org) developed at TIGR is a tool for identification of microbial and viral pathogens and their associated genomic sequences based on the associated epidemiological data. G...
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Protocol
Resources for Genetic and Genomic Studies of Xenopus
The National Institutes of Health Xenopus Initiative is a concerted effort to interact with the Xenopus research community to identify the community’s needs; to devise strategies to meet those needs; and to suppo...
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Article
An ATP-binding cassette gene (ABCG3) closely related to the multidrug transporter ABCG2 (MXR/ABCP) has an unusual ATP-binding domain
