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Article
Open AccessDownregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased...
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Article
Experimental Study on the Effects of Lateral Constraints on the Deformation and Mechanical Properties of Compacted Loess
This research examines the impact of lateral constraints on the deformation and mechanical properties of compacted loess, a prevalent material for road construction foundations. Through laboratory compression ...
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Article
Open AccessPocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery
We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit finding activity in the drug discovery process. This workflow utilized a three-dimensiona...
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Article
Open AccessS100A9+CD14+ monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function
The paucity of reliable biomarkers for predicting immunotherapy efficacy in patients with advanced hepatocellular carcinoma (HCC) has emerged as a burgeoning concern with the expanding use of immunotherapy. Th...
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Article
Open AccessLarge-scale cultural heritage conservation and utilization based on cultural ecology corridors: a case study of the Dongjiang-Hanjiang River Basin in Guangdong, China
In the field of world heritage conservation, there has been broad consensus on carrying out heritage conservation research on the basis of spatial integration and interregional and international cooperation. H...
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Article
Association of obesity with cardiovascular disease in the absence of traditional risk factors
The association between obesity and cardiovascular disease (CVD) in people without traditional CVD risk factors is unclear. This study aimed to investigate the association of obesity with CVD and its subtypes ...
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Article
Carbon neutrality endeavors: the impact of carbon emission trading policies on total factor carbon emission efficiency
Deepening the carbon market allocation reform is a strong support for carbon peaking and carbon neutrality. China has been piloting carbon trading in batches since 2013. However, there is little literature on ...
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Article
Open AccessDifferential perovskite hemispherical photodetector for intelligent imaging and location tracking
Advanced photodetectors with intelligent functions are expected to take an important role in future technology. However, completing complex detection tasks within a limited number of pixels is still challengin...
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Article
Open AccessCation-π interactions enabled water-stable perovskite X-ray flat mini-panel imager
Sensitive and stable perovskite X-ray detectors are attractive in low-dosage medical examinations. The high sensitivity, tunable chemical compositions, electronic dimensions, and low-cost raw materials make pe...
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Chapter and Conference Paper
Co-GAN: A Text-to-Image Synthesis Model with Local and Integral Features
Text-to-Image synthesis is a promising technology that generates realistic images from textual descriptions by deep learning model. However, the state-of-the-art text-to-image synthesis models often struggle t...
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Chapter and Conference Paper
Image Recognition Technology of UAV Tracking Navigation Path Based on ResNet
The image of UAV tracking navigation path is easily affected by noise, and there are problems of low image recognition accuracy and poor image enhancement effect. Therefore, a ResNet-based image recognition te...
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Article
Aggregation behavior and structural properties of Ti3Al nanoparticles
Molecular dynamic (MD) simulations were used to investigate the aggregation process of Ti3Al nanoparticles (NPs) of varying sizes. The aggregation behavior of Ti3Al NPs can be divided into four stages: stable con...
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Article
Open AccessLncRNA SNHG14 activates autophagy via regulating miR-493-5p/Mef2c axis to alleviate osteoporosis progression
Osteoporosis is a progressive bone disease caused by impaired function of endogenous bone marrow-derived mesenchymal stem cells (BMSCs). Herein, we investigated the mechanism of lncRNA SNHG14 in osteoporosis p...
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Article
Effect modification by high-concentration duration in the association between particulate matters and stroke hospital admissions among hypertension patients in Bei**g, China
To investigate the associations between particulate matter (PM) and hospital admissions for stroke and its subtypes among hypertension patients. We proposed a new modifier named high-concentration duration (HC...
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Article
Characteristics Analysis of Sub-Synchronous Oscillation Caused by DFIG Wind Farm Integrated Into MMC-HVDC System
With the increasing share of renewable energy such as wind energy in power system, flexible DC transmission technology has become an important way to effectively absorb wind energy. But the problem of synchron...
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Article
Open AccessDynamic characteristics and reinforcement mechanism of silty soil improved by regenerated fiber polymer
The development of economical and efficient roadbed silt reinforcement technology not only guides the proficient utilization of silt resources but also fosters the green development of geotechnical engineering...
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Article
Digital 3D system for classifying fabric pilling based on improved active contours and neural network
In this paper, we proposed an objective 3D evaluation system of pilling. It can be applied to fabrics with intricate patterns and textures. The major features of the pilling evaluation system include a 3D fabr...
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Article
Open AccessTamoxifen exerts anti-peritoneal fibrosis effects by inhibiting H19-activated VEGFA transcription
Peritoneal dialysis (PD) remains limited due to dialysis failure caused by peritoneal fibrosis. Tamoxifen (TAM), an inhibitor of estrogen receptor 1 (ESR1), has been reported to treat fibrosis, but the underly...
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Article
Investigating the Shear Strength Characteristics of Slip Zone Soil Based on In-situ Multiple Shear Tests
Investigating the shear strength characteristics of sliding zone soil is crucial for evaluating slope safety and stability. This paper discusses the shear strength characteristics of Lishi loess and N2 laterite i...
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Article
Open AccessChange of temperature field around different drainage structures in cold region tunnel based on model testing
Improper layout of drainage structures and inadequate insulation measures in cold tunnels can result in varying degrees of frost formation during operation. This study focuses on the Hongtoushan highway tunnel...
