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  1. Article

    Open Access

    IL-21 and IFNα therapy rescues terminally differentiated NK cells and limits SIV reservoir in ART-treated macaques

    Unlike HIV infection, which progresses to AIDS absent suppressive anti-retroviral therapy, nonpathogenic infections in natural hosts, such African green monkeys, are characterized by a lack of gut microbial tr...

    Justin Harper, Nicolas Huot, Luca Micci, Gregory Tharp, Colin King in Nature Communications (2021)

  2. No Access

    Article

    CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

    The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymp...

    Justin Harper, Shari Gordon, Chi Ngai Chan, Hong Wang, Emily Lindemuth in Nature Medicine (2020)

  3. No Access

    Article

    Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression

    Understanding the resistance of natural hosts of simian immunodeficiency virus (SIV)—such as sooty mangabeys—to disease progression may yield insights applicable to HIV-1. In this issue, Paiardini et al. report t...

    Mirko Paiardini, Barbara Cervasi, Elane Reyes-Aviles, Luca Micci in Nature Medicine (2011)