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Open AccessLimited impact of fingolimod treatment during the initial weeks of ART in SIV-infected rhesus macaques
Antiretroviral therapy (ART) is not curative due to the persistence of a reservoir of HIV-infected cells, particularly in tissues such as lymph nodes, with the potential to cause viral rebound after treatment ...
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CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption
The primary human immunodeficiency virus (HIV) reservoir is composed of resting memory CD4+ T cells, which often express the immune checkpoint receptors programmed cell death protein 1 (PD-1) and cytotoxic T lymp...
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Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells
Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain replication-competent virus1–
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Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression
Understanding the resistance of natural hosts of simian immunodeficiency virus (SIV)—such as sooty mangabeys—to disease progression may yield insights applicable to HIV-1. In this issue, Paiardini et al. report t...
