-
Article
SARS-CoV-2-related peptides induce endothelial-to-mesenchymal transition in endothelial capillary cells derived from different body districts: focus on membrane (M) protein
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV‐2), responsible for the COVID-19, may lead to multiple organ dysfunctions and long-term complications. The induction of microvascular dysfunction i...
-
Article
Open AccessExperimental colitis in young Tg2576 mice accelerates the onset of an Alzheimer’s-like clinical phenotype
Systemic inflammation and neuroinflammation affect the natural course of the sporadic form of Alzheimer’s disease (AD), as supported by epidemiological and preclinical data, and several epidemiological studies...
-
Article
Open AccessMolecular mechanisms of skin wound healing in non-diabetic and diabetic mice in excision and pressure experimental wounds
Experimental models for chronic skin lesions are excision and pressure ulcer, defined as “open” and “closed” lesions, respectively, only the latter characterized by tissue hypoxia. Moreover, systemic diseases,...
-
Chapter and Conference Paper
Clinical and Pathological Features of Severe Gut Dysmotility
Severe gut motility disorders are characterized by ineffective propulsion of intestinal contents. As a result, patients often develop extremely uncomfortable symptoms, ranging from nausea and vomiting along wi...
-
Chapter
Nerve Growth Factor: The First Molecule of the Neurotrophin Family
Neurotrophins (NTs) are molecules regulating differentiation, maintenance, and functional plasticity of vertebrate nervous systems. Nerve growth factor (NGF) was the first to be identified in the neurotrophin ...
-
Chapter
NGF and Endogenous Regeneration: From Embryology Toward Therapies
The self-repair ability of tissues and organs in case of injury and disease is a fundamental biological mechanism and an important therapeutic target. The tissue plasticity and the presence of adult stem cell ...
-
Article
Open AccessFatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients
Clinical features and natural history of coronavirus disease 2019 (COVID-19) differ widely among different countries and during different phases of the pandemia. Here, we aimed to evaluate the case fatality ra...
-
Article
Treatment of severe periodontitis with a laser and light-emitting diode (LED) procedure adjunctive to scaling and root planing: a double-blind, randomized, single-center, split-mouth clinical trial investigating its efficacy and patient-reported outcomes at 1 year
Broad methodological heterogeneity makes the literature on the clinical effects of laser treatment in periodontitis, both as monotherapy and adjunct to non-surgical therapy, which is difficult to interpret. Th...
-
Article
Open AccessErratum: REAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
Scientific Reports 6: Article number: 35719; published online: 24 October 2016; updated: 18 November 2016.
-
Article
Open AccessREAC technology modifies pathological neuroinflammation and motor behaviour in an Alzheimer’s disease mouse model
The search for new therapeutic approaches to Alzheimer disease (AD) is a major goal in medicine and society, also due to the impressive economic and social costs of this disease. In this scenario, biotechnolog...
-
Article
Open AccessIn vitro exposure to very low-level laser modifies expression level of extracellular matrix protein RNAs and mitochondria dynamics in mouse embryonic fibroblasts
Low-level lasers working at 633 or 670 nm and emitting extremely low power densities (Ultra Low Level Lasers - ULLL) exert an overall effect of photobiostimulation on cellular metabolism and energy balance. In...
-
Article
Open AccessPharmacological targeting of the β-amyloid precursor protein intracellular domain
Amyloid precursor protein (APP) intracellular domain (AICD) is a product of APP processing with transcriptional modulation activity, whose overexpression causes various Alzheimer's disease (AD)-related dysfunc...
-
Article
Open AccessMulti-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
Alzheimer disease is a multifactorial disorder characterized by the progressive deterioration of neuronal networks. The pathological hallmarks includes extracellular amyloid plaques and intraneuronal neurofibr...
-
Article
Open AccessGender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis
Multiple sclerosis (MS) varies considerably in its incidence and progression in females and males. In spite of clinical evidence, relatively few studies have explored molecular mechanisms possibly involved in ...
-
Article
Ultra-low-level laser therapy
A growing number of laboratory and clinical studies over the past 10 years have shown that low-level laser stimulation (633 or 670 nm) at extremely low power densities (about 0.15 mW/cm2), when administered throu...
-
Article
Open AccessLow infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress
Considerable interest has been aroused in recent years by the well-known notion that biological systems are sensitive to visible light. With clinical applications of visible radiation in the far-red to near-in...
