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Open AccessConstruction and validation of prognostic signature for hepatocellular carcinoma basing on hepatitis B virus related specific genes
Hepatocellular carcinoma (HCC) is a frequent primary liver cancer, and it is one of the leading cause of cancer-related deaths. Hepatitis B virus (HBV) infection is a crucial risk factor for HCC. Thus, this st...
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Open AccessCathelicidin antimicrobial peptide (CAMP) gene promoter methylation induces chondrocyte apoptosis
The occurrence of osteoarthritis is related to genetic and environmental factors. Among them, the change of chondrocyte gene expression pattern regulated by epigenetic modification is an important participant....
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Article
Alpha 1-antichymotrypsin may be a biomarker for the progression of amnestic mild cognitive impairment
Alpha 1-antichymotrypsin (ACT), an acute-phase protein, has been reported to be increased in the brain and blood of Alzheimer’s disease (AD) patients. However, few previous studies have focused on amnestic mil...
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Open AccessPredicting 30-days mortality for MIMIC-III patients with sepsis-3: a machine learning approach using XGboost
Sepsis is a significant cause of mortality in-hospital, especially in ICU patients. Early prediction of sepsis is essential, as prompt and appropriate treatment can improve survival outcomes. Machine learning ...
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Open AccessUpregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease
In Alzheimer’s Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guan...
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The endoplasmic reticulum stress-autophagy pathway is involved in apelin-13-induced cardiomyocyte hypertrophy in vitro
Apelin is the endogenous ligand for the G protein-coupled receptor APJ, and plays important roles in the cardiovascular system. Our previous studies showed that apelin-13 promotes the hypertrophy of H9c2 rat c...
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Article
Open AccessReduced RCE1 expression predicts poor prognosis of colorectal carcinoma
As an end-proteolytic enzyme that cleaves the last three residues of proteins with a terminal CAAX, Ras-converting enzyme 1 (RCE1) has an essential role in multiple signaling pathways and take part in the proc...
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The TBK1-OPTN Axis Mediates Crosstalk Between Mitophagy and the Innate Immune Response: A Potential Therapeutic Target for Neurodegenerative Diseases
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Low absolute CD4+ T cell counts in peripheral blood are associated with inferior survival in follicular lymphoma
Host immunity and tumor microenvironment significantly influence follicular lymphoma (FL) outcomes. Lymphopenia has been identified as a negative prognostic factor for FL. However, there is limited data regard...
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Article
Progesterone Attenuates Aquaporin-4 Expression in an Astrocyte Model of Ischemia/Reperfusion
Previous studies have suggested that progesterone may be involved in neuroprotection by preventing brain edema. In this study, we assessed the effects of progesterone on aquaporin-4 (AQP4) expression in an isc...
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Meridian–Viscera Correlationship
Meridians and collaterals are considered to be objective entities in the human body. Meridian theory is a foundational component of traditional Chinese medicine (TCM). In traditional acupuncture, doctors are g...
