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Article
Open AccessPlasma levels and tissue expression of soluble TGFβrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study
Mammary carcinogenesis is partly regulated by the transforming growth factor beta (TGFβ) signaling pathway. Its function in cancer progression and metastasis is highly dependent on disease stage, and it is lik...
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Chapter
BMPs in Inflammation
Bone morphogenetic proteins are regulators of embryonic development with multiple functions in adult organs and tissues. Here we summarize effects of BMPs outside the musculoskeletal system, focused on their r...
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Chapter
Osteogrow: A Novel Bone Graft Substitute for Orthopedic Reconstruction
Complications associated with the clinical use of BMP2 and BMP7 result from the limited understanding of their molecular mechanisms in bone remodeling. Recently, a novel BMP6-based approach has been developed ...
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Chapter
Bone Morphogenetic Protein-7 and Its Role in Acute Kidney Injury and Chronic Kidney Failure
Bone morphogenetic protein (BMP)-7 is required for embryonic kidney development, plays a functional role in the adult kidney as renal hormone for vascular and skeletal integrity, and modulates calcium and phos...
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Reference Work Entry In depth
Bone Morphogenetic Proteins in Inflammation
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Living Reference Work Entry In depth
Bone Morphogenetic Proteins in Inflammation
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Article
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
Jodie Babitt and colleagues report that Bmp6-null mice have a phenotype that resembles hereditary hemochromatosis, with increased serum iron concentration and tissue iron overload. Administration of Bmp6 incre...