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Article
Gender-specific effects of prenatal mixed exposure to serum phthalates on neurodevelopment of children aged 2–3 years:the Guangxi Birth Cohort Study
Phthalates have been shown to have adverse effects on neurodevelopment, which may be gender-specific. However, the association between prenatal mixed exposure to phthalates and children’s neurodevelopment rema...
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Article
Open AccessCirculating exosomal mRNA signatures for the early diagnosis of clear cell renal cell carcinoma
There are no proven tumor biomarkers for the early diagnosis of clear cell renal cell carcinoma (ccRCC) thus far. This study aimed to identify novel biomarkers of ccRCC based on exosomal mRNA (emRNA) profiling...
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Article
Causal Effect of Genetically Determined Blood Copper Concentrations on Multiple Diseases: A Mendelian Randomization and Phenome-Wide Association Study
Exposures to copper have become a health concern. We aim to explore the broad clinical effects of blood copper concentrations. A total of 376,346 Caucasian subjects were enrolled. We performed a Mendelian rand...
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Article
Open AccessGenome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans
Metal elements are present in the human body, and their levels in the blood have important impacts on health. In this study, 2488 Chinese individuals were included in a genome-wide association study of 21 seru...
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Article
The impacts of different anticoagulants and long-term frozen storage on multiple metal concentrations in peripheral blood: a comparative study
It is important but remains unclear whether ethylenediaminetetraacetic acid (EDTA) and sodium heparin anticoagulants have different impacts on the levels of various metals in peripheral blood after long-term f...
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Article
Causal Relationship Between Complement C3, C4, and Nonalcoholic Fatty Liver Disease: Bidirectional Mendelian Randomization Analysis
The complement system is activated during the development of nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the causal relationship between serum C3 and C4 levels and NAFLD. After exclusion cri...
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Article
Associations Between Serum Multiple Metals Exposures and Metabolic Syndrome: a Longitudinal Cohort Study
Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relation...
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Article
Open AccessHigh manganese exposure decreased the risk of high triglycerides in workers: a cross-sectional study
Manganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.
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Article
Association between long-term occupational manganese exposure and bone quality among retired workers
Despite well documents for manganese-induced neurological deficits, limited researches are available for effects of manganese (Mn) exposure on the bone. Here we aimed to explore the associations between long-t...