60 Result(s)

Article

High-resolution spatiotemporal map**: a comprehensive view of eukaryotic cell cycle proteome dynamics

**g Zou, Ziran Qin, Long Zhang in Signal Transduction and Targeted Therapy (2024)

Article

PARP1-DNA co-condensation: the driver of broken DNA repair

**ang Wei, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2024)

Article

MiR-134-5p inhibits the malignant phenotypes of osteosarcoma via ITGB1/MMP2/PI3K/Akt pathway

Micro RNAs (miRs) have been implicated in various tumorigenic processes. Osteosarcoma (OS) is a primary bone malignancy seen in adolescents. However, the mechanism of miRs in OS has not been fully demonstrated...

Lei Yan, Ruhao Zhou, Yi Feng, Ruoqi Li, Long Zhang, Yongchun Pan… in Cell Death Discovery (2024)

Article

R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis

R-spondins (RSPOs) are secreted signaling molecules that potentiate the Wnt/β-catenin pathway by cooperating with Wnt ligands. RSPO1 is crucial in tissue development and tissue homeostasis. However, the molecu...

Lifeng Tan, Mengfang Yan, Zijie Su, Hanbin Wang… in Cell Communication and Signaling (2024)

Article

IDH1/MDH1 deacetylation promotes acute liver failure by regulating NETosis

Acute liver failure (ALF) is a life-threatening disease, but its pathogenesis is not fully understood. NETosis is a novel mode of cell death. Although the formation of neutrophil extracellular traps (NETs) has...

Yukun Wang, Chunxia Shi, ** Guo, Danmei Zhang… in Cellular & Molecular Biology Letters (2024)

Article

M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma

Metastasis is a key feature of malignant tumors and significantly contributes to their high mortality, particularly in hepatocellular carcinoma (HCC). Therefore, it is imperative to explore the mechanism of tu...

Yiwei Lu, Guoyong Han, Yao Zhang, Long Zhang, Zhi Li… in Cell Communication and Signaling (2023)

Article

Activated STING: an ion channel to trigger non-interferon-related functions

Zhengyu Gao, Bin Wang, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition

Sijia Liu, Jiang Ren, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

circACTA2 inhibits NLRP3 inflammasome-mediated inflammation via interacting with NF-κB in vascular smooth muscle cells

circACTA2 derived from the smooth muscle α-actin gene plays an important role in the regulation of vascular smooth muscle cell (VSMC) phenotype. The activation of NLRP3 inflammasome is involved in VSMC phenoty...

Yang Bai, Long Zhang, Bin Zheng, **nhua Zhang… in Cellular and Molecular Life Sciences (2023)

Article

Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood

Ran Li, **g Zou, Dongling Pei, Ting Pan… in Signal Transduction and Targeted Therapy (2023)

Article

The loss of epigenetic information: not only consequences but a cause of mammalian aging

Chen Pan, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

Motile cilia and microvillar: accomplices of SARS-CoV-2 in penetrating mucus barrier and infecting airway epithelium

Peng Su, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

The fungal mycobiome: a new hallmark of cancer revealed by pan-cancer analyses

Zhi Zong, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2023)

Article

Assay establishment and validation of a high-throughput organoid-based drug screening platform

Organoids are three-dimensional structures that closely recapitulate tissue architecture and cellular composition, thereby holding great promise for organoid-based drug screening. Although growing in three-dim...

**aomeng Li, Guoxiang Fu, Long Zhang, Ruoyu Guan… in Stem Cell Research & Therapy (2022)

Article

Alterations in microbiota of patients with COVID-19: potential mechanisms and therapeutic interventions

The global coronavirus disease 2019 (COVID-19) pandemic is currently ongoing. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A high proportion of COVID-19 patients exhibit gastro...

Bin Wang, Lei Zhang, Yongqiang Wang, Tong Dai… in Signal Transduction and Targeted Therapy (2022)

Article

SARS-CoV-2 Omicron variant: recent progress and future perspectives

Since the outbreak of the coronavirus disease 2019 (COVID-19) pandemic, there have been a few variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), one of which is the Omicron variant (...

Yao Fan, **ang Li, Lei Zhang, Shu Wan… in Signal Transduction and Targeted Therapy (2022)

Article

Novel pyroptosis-independent functions of gasdermins

Ziran Qin, Fangfang Zhou, Long Zhang in Signal Transduction and Targeted Therapy (2022)