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Article
Open AccessVariants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology
Recent evidence suggests that Alzheimer’s disease (AD) genetic risk variants (rs1582763 and rs6591561) of the MS4A locus are genome-wide significant regulators of soluble TREM2 levels such that the minor allele o...
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Article
Open AccessTREM2 gene expression associations with Alzheimer’s disease neuropathology are region-specific: implications for cortical versus subcortical microglia
Previous post-mortem assessments of TREM2 expression and its association with brain pathologies have been limited by sample size. This study sought to correlate region-specific TREM2 mRNA expression with diverse ...
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Article
Open AccessLarge multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease
Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in the brain and to study Alzheimer’s disease (AD). We performed a genome-wide association study on the largest...
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Article
Open AccessAlzheimer’s disease genetic risk and cognitive reserve in relationship to long-term cognitive trajectories among cognitively normal individuals
Both Alzheimer’s disease (AD) genetic risk factors and indices of cognitive reserve (CR) influence risk of cognitive decline, but it remains unclear whether they interact. This study examined whether a CR inde...
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Article
Open AccessProtective genes and pathways in Alzheimer’s disease: moving towards precision interventions
Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that is characterized by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks. The etiology of Alzheim...
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Article
Open AccessBrain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer’s disease
Vascular endothelial growth factor (VEGF) is associated with the clinical manifestation of Alzheimer’s disease (AD). However, the role of the VEGF gene family in neuroprotection is complex due to the number of...
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Article
Author Correction: Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Sex Differences in the Genetic Architecture of Alzheimer’s Disease
Summarize sex-specific contributors to the genetic architecture of Alzheimer’s disease (AD).
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Article
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
Alzheimer’s disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undis...
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Article
Sex-specific genetic predictors of Alzheimer’s disease biomarkers
Cerebrospinal fluid (CSF) levels of amyloid-β 42 (Aβ42) and tau have been evaluated as endophenotypes in Alzheimer’s disease (AD) genetic studies. Although there are sex differences in AD risk, sex differences...
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Article
Genetic resilience to amyloid related cognitive decline
Preclinical Alzheimer’s disease (AD) is characterized by amyloid deposition in the absence of overt clinical impairment. There is substantial heterogeneity in the long-term clinical outcomes among amyloid posi...
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Article
Open AccessTowards a phenome-wide catalog of human clinical traits impacted by genetic ancestry
Racial/ethnic differences for commonly measured clinical variables are well documented, and it has been postulated that population-specific genetic factors may play a role. The genetic heterogeneity of admixed...
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Article
Open AccessThe effects of electronic medical record phenoty** details on genetic association studies: HDL-C as a case study
Biorepositories linked to de-identified electronic medical records (EMRs) have the potential to complement traditional epidemiologic studies in genotype-phenotype studies of complex human diseases and traits. ...
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Article
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modif...
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Article
Open AccessInvestigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
High-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels are influenced by both genes and the environment. Genome-wide association studies (GWAS) ...
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Article
Serum vitamins A and E as modifiers of lipid trait genetics in the National Health and Nutrition Examination Surveys as part of the Population Architecture using Genomics and Epidemiology (PAGE) study
Both environmental and genetic factors impact lipid traits. Environmental modifiers of known genotype–phenotype associations may account for some of the “missing heritability” of these traits. To identify such...
