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  1. No Access

    Article

    Deciphering the Antidiarrheal Mechanisms of Macleaya cordata by Combining Network Pharmacology, Molecular Docking, and Experimental Evaluations

    Diarrhea continues to be a major public health problem and is thought to be the cause of 525,000 child fatalities annually. Studies have shown that Macleaya cordata (Willd.) R.Br., Papaveraceae, has a good therap...

    Liyang Guo, Xuexue Xue, Yang Zhou, Chunli Chen… in Revista Brasileira de Farmacognosia (2024)

  2. No Access

    Article

    Assessment of the Antidiarrheal Activity and Chemical Composition of Dichloromethane Extract from Macleaya Cordata

    Macleaya cordata (Willd.) R.Br., Papaveraceae, is a traditional Chinese herb, and it has been proven to have good antimicrobial, anti-inflammatory, and antidiarrheal properties. However, its antidiarrheal constit...

    Liyang Guo, Liwen Ai, Fan Yang, Weixue Liu… in Revista Brasileira de Farmacognosia (2022)

  3. No Access

    Article

    MicroRNA-155 expression is associated with pulpitis progression by targeting SHIP1

    Pulpitis is a commonly seen oral inflammation condition in clinical practice, it can cause much pain for the patient and may induce infections in other systems. Much is still unknown for the pathogenic mechani...

    Baishun Li, Liyang Guo, Ying He, **nran Tu, Jialin Zhong… in Molecular Biology Reports (2022)

  4. No Access

    Article

    Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice

    Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of schizophrenia via the microbiota–gut–brain axis. This study sought to investigate whether transplantation of fecal microbi...

    Feng Zhu, Rui** Guo, Wei Wang, Yanmei Ju, Qi Wang, Qingyan Ma… in Molecular Psychiatry (2020)

  5. Article

    Open Access

    LncRNA H19 promotes odontoblastic differentiation of human dental pulp stem cells by regulating miR-140-5p and BMP-2/FGF9

    Increasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a critical process for dentin formation, odontoblastic differentiation is regulated by...

    Jialin Zhong, **nran Tu, Yuanyuan Kong, Liyang Guo… in Stem Cell Research & Therapy (2020)

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  6. Article

    Open Access

    Metagenome-wide association of gut microbiome features for schizophrenia

    Evidence is mounting that the gut-brain axis plays an important role in mental diseases fueling mechanistic investigations to provide a basis for future targeted interventions. However, shotgun metagenomic dat...

    Feng Zhu, Yanmei Ju, Wei Wang, Qi Wang, Rui** Guo, Qingyan Ma… in Nature Communications (2020)

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