3 Result(s)
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Lisa M. Häsler
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessMedin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently kno...
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Article
Open AccessExperimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but the long presymptomatic phase and poor correlation between Aβ deposition and clinical symptoms remain puzzling. To ...
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Article
Innate immune memory in the brain shapes neurological disease hallmarks
Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distin...
